Abstract
Extracellural administration of adenosine triphosphate has been known as potent vasodilator and has been used for the treatment of hemorrhagic shock or intentional hypotensive anesthesia.
But the mechanism of its action on vascular smooth muscle has not been studied sufficiently yet.
On the isolated spiral-cut aortic strip of the rabbit, adenosine triphosphate showed inhihitory action on the phenylephrine dose-response curve of the strip dose-dependently.
The aortic strips, brought to the half-maximal contracted state by phenylephrine or histamine were relaxed by adenosine triphosphate as the same manner as lidocaine and quite different from those of phenoxybenzamine, diphenhydramine and isoproterenol.
These findings suggested that adenosine triphosphate may act as a non-specific vasodilator on the vascular smooth muscle.
