STUDIES ON DRUG HYPERSENSITIVITIES

1. Drug hypersensitivities in patients with bronchial asthma

Abstract

Generally speaking, in patients with bronchial asthma, high incidence of drug hypersensitivities has been reported.
Patients with bronchial asthma (188 males and 261 females) were investigated on drug hypersensitivities in contradistinction to healthy subjects (1978 males and 190 females) that belong to a company in Tokyo. The following results were obtained :
(1) Incidence of drug hypersensitivities in patients was significantly higher (26.1%) than healthy subjects (4.5 %) .
(2) In both groups, in females higher incidence of drug hypersensitivities was proved.
(3) Incidence in mixed type of bronchial asthma was higher than atopic or infectious type.
(4) Incidence of the drug induced asthma in patients was 6.7% (30/449) and incidence so called aspirin asthma was 3.3% (15/449) .
(5) Clinical manifestations and kinds of the drugs induced hypersensitivities were no significant differences between patients and healthy subjects.