Abstract
Pyrine allergy is one of the well-known drug hypersensitivities. But, Mechanisms of pyrine allergy are still not well understood. It is generally accepted that pyrines themselves were unable to be antigenecity, but they must combine irreversibly with carrier protein in order to gain antigenecity.
In this study, using pyrine metabolites and their protein complexes as antigen, RAST, leucolytic reaction, hemagglutination test, intracutaneous reaction and precipitation test were carried out to clarify pyrine allergy. The following results were obtained:
A few cases used pyrine metabolites and protein binding compexes as antigen showed positive in leucolytic reaction and intracutaneous reaction, though cases used pyrine (sulpyrine) itself as antigen showed negative.
It is paramount of importance to be metabolized and combine with carrier protein in order to develop pyrine allergy.
