1979 年 39 巻 5 号 p. 495-505
It has been said that the pancreatic secretion is related with autonomic nerves and humoral factors, but mechanism of the pancreatic secretion is not proved in detail. In this series, the effect of 6-Hydroxydopamine (=60 HDA) that causes the chemical sympathectomy, on the change of the pancreatic exocrine secretion was examined by measuring the pancreatic blood flow and the volume of pancreatic juice.
As the results, the volume of pancreatic juice was decreased and its bicarbonate concentration was deteriorated markedly after 6-OHDA administration.
In addition, the effect of secretin on the pancreatic blood flow was not affected after administration of 6-OHDA. On the other hand, the pancreatic exocrine secretion was increased by vagal stimulation, and the volume of pancreatic juice increased 146.2% on the average. But after administration of 6-OHDA, the pancreatic secretion was disappeared by vagal stimulation, but accelerated by L-Dopa administration.
Becausa 6-OHDA depletes the adrenergic amines from the sympathetic nerve terminals, if the pancreatic exocrine secretion is controlled only by the factor of blood flow, it should be accelerated with the increase of pancreatic blood flow after 6-OHDA administration. However in this studies, not only the nervous pancreatic secretion by vagal stimulation but also humoral secretion of pancreas was inhibited after 6-OHDA administration. From this, I considered that 6-OHDA acted on a factor except the blood flow. Namely, the inhibition of pancreatic secretion by 6-OHDA depends on the decrease of dopamine because 6-OHDA depletes not only noradrenalin but also dopamine. In this studies, the fact that the nervous and humoral pancreatic secretion were inhibited by 6-OHDA administration suggests the existence of charactor like the endocrine cell in the exocrine cell and the possibility that the production of pancreatic juice and synthesis of dopamine take place in the cells. Since amines contained in endocrine cells were concerned with the mechanism of endocrine secretion, exocrine secretion was affected by amines equally and then pancreatic exocrine secretion was caused by dopamine.