Abstract
We investigated the effects of combined administration or after treatment of NKK-105 and its rerated compounds on the ethionine-induced fatty liver in the rats, and obtained the following results.
1) The liver/body weight ratio decreased by the administration of ethionine (250mg/ kg, s. c. daily for 4 days) .
An decrease of liver/body weight ratio by ethionine inhibited by the administration of NKK-105 and its related compounds with a dose of 50 mg/kg, p.o. But NKK-105 and its related compounds 250 mg/kg, p.o. administered group showed an increase of liver/body weight ratio more than control group.
2) Ethionine administered group showed a decrease in protein contents of liver and serum.
NKK-105 and its related compounds inhibited the decrease of protein by the administration of ethionine, especially in NKK-105, 250 mg/kg, p. o. administered group and it was showed an increase of protein more than control group.
3) The liver lipid contents of ethionine administered group showed a significantly increase in total lipid (TL), total choresterol (TC) and triglyceride (TG) and a decrease in phospholipid (PL) .
NKK-105 and its related compounds inhibited the increase of TL, TC and TG and decrease of PL by the administration of ethionine.
4) The serum lipid contents of ethionine administered group showed a decrease of TL, TC, TG and PL.
NKK-105 and its related compounds inhibited the decrease of serum lipid contents by the administration of ethionine. NKK-105, 250 mg/kg, p.o. administered group showed an increase of over control group.
5) The rise of serum transaminase activity was observed by the administration of ethionine. This transaminase activity rising action of ethionine was inhibited by the admi-nistration of NKK-105 and its related compounds.
6) Histologic examination of ethionine-induced fatty liver showed a diffusional fatty degeneration and centrilobular necrosis.
NKK-105 showed an inhibitory effect of these histological response to ethionine administration.
