Diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) の薬理学的研究 (第VI報) 抗原性ならびに網内系に及ぼす影響

抄録

Antigenicity of, NKK-105 and its solvent were studied with immunological procedures. Immunopharmacological tests in guinea pigs included active and passive anaphylaxis, passive cutaneous anaphylaxis, reversed passive Arthus reaction and Schultz-Dale reaction. NKK-105 and its solvent showed negative results on their antigenicity compared with positive ones of horse serum. Effect of NKK-105 and its solvent on reticuloendothelial system were studied by means of carbon clearance test. The solvent of NKK-105 showed reticuloendothelial stimulating effect and Zymosan as the reticuloendothelial stimulant showed stronger activity.