Abstract
1) The distribution of radio-activity in the body were observed after intravenous injection of three different radiocolloids (198Au-colloid, 99mTc-phytate, 99mTc-Sn-colloid) .
2) The larger the particles such as 99mTc-Sn-colloid were, the more accumulated in the spleen and the lung.
3) The diluted solution of these colloids was apt to accumulate greater in spleen than control groups.
4) Even if havey dose injection of non radiocolloid, there was not so distingishable change in scintigraphic images of radiocolloid.
5) The reaction to stimulation of RES by endotoxin and others was the most remarkable in Sn-colloid and in the lung or the spleen.
6) When endotoxin was given after radiocolloid was distributed, there was no influence to the radiocolloidal distribution in the body.
7) Both the size of colloid and physiological change have an effect on the colloidal distribution in the body. Especially, accumulation of 99mTc-Sn-colloid in the lung would be able to have connection with clinical disorders.
