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Volume 40 (1980)
- Issue 6 Pages 647-
- Issue 5 Pages 525-
- Issue 4 Pages 401-
- Issue 3 Pages 277-
- Issue 2 Pages 149-
- Issue 1 Pages 1-
Volume 40, Issue 5
Displaying 1-14 of 14 articles from this issue
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Hajime YASUHARA, Shinichi KOBAYASHI, Osamu UMEZAWA, Koji SAKAMOTO, Kaz ...1980 Volume 40 Issue 5 Pages 525-530
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDrugs prescribed in outpatients were surveyed for one week in Showa University Hospital. The present study is based on 4, 065 prescriptions in 7, 787 outpatients.
From the results of the percentage of prescriptions prescribed in outpatients in each clinic, it was obtained to be 83% in psychiatry-clinic, 72% in urology-clinic, 69% in dermatology-clinic, 64% in internal medicine-clinic, 59% in paediatrics-clinic and these data indicated that outpatients in psychiatry-clinic were depended on drug therapy. The most frequent prescribing drugs in outpatients were sedatives, which were prescribed in all clinical departments. Antiinflammatory drugs, antacid, vitamin which would be commonly prescribed with the other drugs for oral use will be necessary to reevaluate for their therapeutic effects and interactions. The number of prescribing remedies for oral use in outpatients was obtained to increase with increase in age in linear manner in internal medicine for cardiovascular diseases, that is, outpatients under 20 years old were prescribed about 2 or 3 remedies and the number of prescribing remedies was increased in one remedy in every ten years of age and outpatients over 80 years old were prescribed about 8 remedies.View full abstractDownload PDF (771K) -
Ryosaku ITO, Keiji IHARA, Satoshi ONDA, Tadanao KIMURA, Teizo AJIRI, H ...1980 Volume 40 Issue 5 Pages 531-544
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe muscle fibers of anterior serratus muscles, trapezius muscles, rhomboideus muscles and atlantoscapular muscles from ten adult crab-eating monkeys (six females and four males) were studied for elucidating the functional characteristics of upper extremities muscles in the anthropoids. The muscle fibers were differentiated by Sudan Black B staining method into two types, termed white and red fibers in respect of fiber staining density, and measured each fiber size and counted each fiber number in certain area of muscles.
Results were following ;
1) The white fiber ratio (the number of white fiber to red fiber per unit area) was more than 1 in cranial and intermediate parts of anterior serratus muscles, and caudal parts of rhomboideus muscles in males, and anterior and posterior atlantoscapular muscles in both sex. In other parts of above muscles and trapezius muscles, the white fiber ratio was less than 1 in males and females.
2) A great number of larger size of white fiber was apparently seen in caudal parts than other parts of anterior serratus as well as rhomboideus muscles, in males and females. In atlantoscapular, anterior parts had many thicker white fibers than posterior parts in males and females. In trapezius, great number of larger white fiber was visible in caudal parts than other parts in appearance. The size of white fiber was mostly larger in males than females, in all parts of all muscles except in the caudal parts of anterior serratus muscles. However, in all cases, the size of red fibers was smaller than that of white fibers.
3) The distribution in the size frequency of muscle fibers was tend to broader in white fiber than red fibers and in thick fiber parts than thin fiber parts. Respect to the body weight and sex, the size of muscle fiber was distributed to widespread in heavy monkey and so in males.
4) In consideration of concerning to movement of scapula, the thickness of muscle layer, the number of muscle fiber per sq, mm. and the size of muscle fiber were the most developed in the parts of muscle which participated in abduction of scapula, second most in the part of which took parts in the motion in cranial-cauda direction of the bone, and small in the parts of which fixed the bone to the body. Those of tendency might be derived from the characteristics of body movement of crab-eating monkey.View full abstractDownload PDF (1514K) -
Akira OTA, Katsuhiko MAYUMI, Akira SHINOZUKA, Eiji SUNADA, Yoshimasa T ...1980 Volume 40 Issue 5 Pages 545-550
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe 99mTc-phosphates have been used as bone scanning agents. Abnormal extraosseous accumulation of 99mTc-phosphates was noted in 10 cases. The lesions associated with extraosseous accumulation are as follows ; 1 breast cancer, 2 neuroblastomas, 1 Wilms' tumor, 1 Hodgkin's disease, 1 rectum carcinoma, 1 pulmonary fibrosis, 1 abdominal wall metastasis of gastric cancer, 1 operation scar and 1 hepatoblastoma. In other several author's reports of abnormal extraosseous accumulation in malignant tumor, it is suggested that 99mTc-phosphate is concentrated in the region where Ca-P metabolism is accelerated.
However, it is known as a fact that positive or negative findings are pointed out even in pathologically same diseases. For interpretation of this mechanism, several opinions have been suggested, but it remains as an unsolved problem.View full abstractDownload PDF (6510K) -
(I) THE DISTRIBUTION OF RADIOCOLLOIDAL PARTICLESYoshimasa TAKAHASHI1980 Volume 40 Issue 5 Pages 551-560
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS1) The distribution of radio-activity in the body were observed after intravenous injection of three different radiocolloids (198Au-colloid, 99mTc-phytate, 99mTc-Sn-colloid) .
2) The larger the particles such as 99mTc-Sn-colloid were, the more accumulated in the spleen and the lung.
3) The diluted solution of these colloids was apt to accumulate greater in spleen than control groups.
4) Even if havey dose injection of non radiocolloid, there was not so distingishable change in scintigraphic images of radiocolloid.
5) The reaction to stimulation of RES by endotoxin and others was the most remarkable in Sn-colloid and in the lung or the spleen.
6) When endotoxin was given after radiocolloid was distributed, there was no influence to the radiocolloidal distribution in the body.
7) Both the size of colloid and physiological change have an effect on the colloidal distribution in the body. Especially, accumulation of 99mTc-Sn-colloid in the lung would be able to have connection with clinical disorders.View full abstractDownload PDF (3702K) -
(II) LUNG UPTAKE OF 99mTc-Sn-COLLOID DURING LIVER SCINTIGRAPHYYoshimasa TAKAHASHI1980 Volume 40 Issue 5 Pages 561-570
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSForty-one cases of RI lung accumulation were selected from 1536 cases among liver scintigraphy of 99mTc-Sn-colloid. The results of analysis of these cases are as follows:
1) The cases of lung accumulation caused by failure of preparing 99mTc-Sn-colloid were excluded. The lung accumulation in liver scintigraphy was able to be found only in 99mTc-Sn-colloid with large sized particle.
2) From several facts, it is not considered that 99mTc-colloid was taken into the lung in form of macroaggregation after injection.
3) The lung accumulation of 99mTc-colloid was not always detected in the cases with any liver disorder.
4) The great majority of cases with the lung accumulation were malignant tumor, the next was liver cirrhosis. When the patients were in the most severe condition, 99mTc-colloid apt to be revealed in the lung. In the cases of children, the marked accumulation of the lung was always observed.
5) The lung accumulation of 99mTc-Sn-colloid was also observed in many patients with splenomegaly without liver disease. It is not a phenomena from the result of decrease in hepatic blood flow or of portal hypertension, but it may be related with certain immunological chnge.
6) Most patients with the lung accumulation were in extremely severe condition and their survival was not so good. Therefore, this phenomena could refer to a indicator of poor prognosis.
7) The lung accumulation of RI colloid may be revealed when patients fall into extremely severe stage and pulmonary macrophages are stimulated. Its phenomena would be essentially caused by a mechanism that RI-colloid are phagocyted by pulmonary macrophages.View full abstractDownload PDF (5559K) -
Eiji SUNADA1980 Volume 40 Issue 5 Pages 571-579
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThirty thousand cells of sarcoma 180 were implanted on the back of C3H mice. The rejecting ability against implanted tumor was observed at the 14 th day after the primary tumor implantation (it is known as concomitant immunity) . This phenomenon depends on increase of T-lymphocytes in spleen with decrease of thymocytes. The re-implanted tumor began to grow at three weeks after surgical removal of the primary tumor. However, the reimplanted tumor never began to grow for a long time after irradiation of the primary tumor.
It is suggested that increase of T-lymphocytes in spleen is related to the rejecting ability against re-implanted tumor growth and continuous existence of small amount of antigen sustains host immunity for a long time.View full abstractDownload PDF (5439K) -
Shuzo KATAO, Yoshio OGAWA, Seiyu YUSA, Masako SATOYOSHI1980 Volume 40 Issue 5 Pages 581-597
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSChanges in blood capillary distribution were studied in skeletal muscle after endurance exercise. Sixty male rats were divided into two groups; an exercised and a non-exercised group. The exercised group was given tredmill running one hour per day for two months, starting two months after birth.
Usually, skeletal muscle fibers are classified into white, red and intermediate fibers. Most of the changes which were observed after endurance exercise were in the red muscle fibers.
The results were as follows: 1) As for the number of blood capillaries per unit area of muscle cross section in specimens the exercised group showed 50 percent higher than in the non-exercised group. 2) Capillary to muscle fiber ratios (C/F ratio) were calculated in different cross section. The C/F ratios in superfisial layers were lower than those in deep layers. 3) According to electron microscope observation, fine structural changes of blood capillaries in skeletal muscle displayed the following two characteristics. First: multiplication of the blood capillaries was accompanied by changes in the endothelium. Second: the formation of bloos capillaries depened on changes in the interstitium which formed fibrous meshs around the plasma.View full abstractDownload PDF (16992K) -
Nobuo HAYASHI, Tamio KUSHIHASHI, Toru HASHIMOTO, Kazunari KIMURA, Taka ...1980 Volume 40 Issue 5 Pages 599-604
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of MnCl2 on MAO activity in dog brain, liver, serum and human placenta were studied radiometrically. At concentrations of 10-3 and 10-2 M, MnCl2 inhibited the oxidation of tyramine, 5-HT and benzylamine by MAO in dog brain, liver and serum. However MAO in human placenta with tyramine as substrate was activated by MnCl2 at concentration of 10-4 M while MAO in human placenta with 5-HT as substrate was inhibited by MnCl2 at concentration of 10-2 M. The activation and the inhibition mechanism of MAO in human placenta by MnCl2 were investigated by the method of Lineweaver-Burk plots using tyramine and 5-HT as substrate, and it was found that the inhibition of MAO by MnCl2 using 5-HT as substrate was noncompetitive one and the activation of MAO by MnCl2 using tyramine as substrate was competitive. On the other hand, it was also found that the activation of MAO by MnCl2 using tyramine as substrate was reversible, and the inhibition of MAO by MnCl2 using 5-HT as substrate was irreversible. These results suggest that there are at least two different forms of MAO in human placenta.View full abstractDownload PDF (614K) -
Hiromi TOKUYAMA1980 Volume 40 Issue 5 Pages 605-610
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe auther examined the alternation in blood gas, acid-base balance, endtidal CO2 concentration, CO2 production and muscle surface pH (of the dog) following rapid intravenous administration with 7% sodium bicarbonate solution. (1 ml/kg)View full abstractDownload PDF (4027K) -
Minoru NOMI, Sadao NAKAYAMA1980 Volume 40 Issue 5 Pages 611-619
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe development of cholinesterase (ChE) and monoamine oxidase (MAO) has been studied in the brain, liver and eye ball of chick embryo and chick, using acetylcholine (ACh), acetyl-β-methylcholine (MeCh), butyrylcholine (BuCh), benzoylcholine (BzCh), benzylamine and tyramine as substrates. ChE activities in the brain of chick embryo and chick were observed in high activities when ACh or MeCh were used as substrates, in addition to a marked increase in the development of the chick embryo and chick.
The ChE of liver reached its peak 15 to 18 days after the incubation of the fertilized egg. The activity of the ChE hydrolysed BuCh in liver was found higher than that of ChE hydrolysed ACh, McCh and BzCh. When ACh or MeCh were used as substrates, the ChE activity of the eye ball was high but not so in the case using BzCh.
MAO activity in brain was found to increase during the incubation of the fertilized egg, and maximum activity was observed 3 days after hatching. An increase of MAO activity in liver and eye ball was found after hatching. These results suggest that most of the ChE activities in chicken were obtained during the embryo period. Inhibition of ChE activity by parathion (0.1 mg/egg) was found in liver alone. Organophosphate (Sumithion and Parathion) has no effect on the MAO activities in liver, brain and eye ball of either chick embryo or chick.View full abstractDownload PDF (1033K) -
Masashi YAMAGUCHI1980 Volume 40 Issue 5 Pages 621-627
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe case of hereditary disease has increased yearly. According to McKusick, there are about 3, 000 kinds of this disease. About seven percent of new born babies are said to have hereditary disease in one form or another.
In the present paper we reported a study on 155 cases we encountered at the Genetic Counseling Center during two years and two months from October, 1977 to December, 1979.
Of the matters brought up for consultation, one concerning intermerriage was the most with 24 cases, followed by schizophrenia, manicdepressive psychosis 20 cases, mental deficiency 15 cases, harelip-palatoschisis 14 cases and so on.
Consultation about hypophosphatasia, Wiskott-Aldrich syndrome, dyschromatopsia and Down's syndrome from among the cases mentioned above were described concretely.
It appears that the latent need for consultation about heredity is considerably high today.View full abstractDownload PDF (691K) -
Michiko YAMADA, Shohei TAKEDA, Ken-ichi KAGAMI, Kimio HONDA1980 Volume 40 Issue 5 Pages 629-633
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe experienced the anesthetic control of two cases which had the thrombocytopenia and tendency of bleeding because of the Kasabach-Merritt syndrome and juvenile liver cirrhosis. The former underwent operation of tumor extirpation successfully after the careful preoperative management. The latter was controlled with general anesthesia without improvement of platelet counts, becuase this case was intended to undergo hepatic angiography which was said to be a safety technique, but we encountered with intratrachial bleeding at intubation. Therefore, we obliged to exchange the anesthetic method.
Thus, we realized keenly that the case which had a tendency of bleeding needed satisfactorily preoperative management and careful anesthetic control.View full abstractDownload PDF (1877K) -
Miki KUSHIMA, Akira SHIOKAWA, Fumio SHINOHARA, Takuro OKADA, Yukio TUR ...1980 Volume 40 Issue 5 Pages 635-638
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSUntil now, many cases with lesions of eoshinophilic infiltration of the stomach have been reported. These lesions are classified into three different types by Tanaka (1975), that is (1) localized polypoid, (2) diffuse thickened and (3) parasitic granulomatous. They are thought to have individually different pathogenesis.
The diffuse thickened type consists with eoshinophilic gastritis, proposed by Doniach and McKeown (1951), and this type is said to have a relationship with allergic lesions and is considered as an uncommon lesion.
Only about 10 similar case reports have been found in the literature in our country.
We have encountered a case with diffuse massive eoshinophilic infiltration of the gastric wall. And the lesion is similar with the diffuse thickened type and eoshinophilic gastritis.
The patient, aged 48, housewife, was diagnosed as gastric cancer because of the deformity of the stomach by the barium-meal radiography. Total gastrectomy was performed.
The totally resected stomach revealed thickening of the wall, especially of musular layer. The lesion extends from the fundus to the antrum of the stomach.
Microscopic study of many sections of the resected stomach showed thickening of the wall due to marked diffuse eoshinophilic infiltration in the submucosa, muscularis, and subserosa, specially muscularis. Slight eoshinophilic infiltration was revealed in the spleen and the surgically biopsied liver.
Ten per cent of eoshinophilic leukocytosis in the peripheral blood was disclosed 2 months after the gastrectomy.
There is no evidence of parasitic infection and no history of allergy in this case. We could not find any allergenic factor in this case.View full abstractDownload PDF (3988K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1980 Volume 40 Issue 5 Pages 639-645
Published: October 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (899K)
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