Abstract
The effect of L-5Hydroxytryptophan (L-5HTP), DL-5Hydroxytryptophan (DL-5HTP) and Benserazide-HCl (Ro4-4602) were investigated on the spinal ventral root reflexes by the intact and spinal cat preparations. These observation indicate that: 1) L and DL-5HTP were increased MSR but were decreased PSR. The effect of L-5HTP was faster than DL-5HTP on the spinal cord facilitation. 2) L-5HTP 75 mg/kg i, v. was not change at the case of the intact cat on neuronal activity. 3) L-5HTP 75 mg/kg by arteria carotis externa injection facilitated a shorter latency and the continuance prolonged. 4) Benserazide-HCl (Ro4-4602) 50 mg/kg i. v. inhibited MSR and PSR but 25 mg/kg i. v, not inhibited MSR and PSR. 5) Benserazide-HCl 25 mg/kg i. v. followed by L-5HTP 75 mg/kg i. v. was not change on the spinal neuronal activity. 6) L-5HTP 75 mg/kg i. v. at the same time Benserazide 25 mg/kg i. v, inhibited MSR but not inhibited PSR. 7) L-5HTP 75 mg/kg i. v, followed by Benserazide-HCl 25 mg/kg i, v. stopped the rising of MSR but not changed PSR. (3) -7) C1-C2 cut, not used dTc) .
