Abstract
Effects of soedomycin, an anticancer agent, and Na2HPO4, its substrate, on general pharmacological and antigenic studies were investigated.
1) Soedomycin and Na2HPO4 showed no effects on mono- and polysynaptic reflex in acute spinal cats, and on blood sugar and serum cholesterol levels in rabbits.
2) Soedomycin and Na2HPO4 showed slight sleeping pattern on EEG and inhibition of spontaneous respiration, while they had tendency to increase on heart rate in chronic rabbits.
3) Soedomycin and Na2HPO4 showed slight contraction on smooth muscles (ileum of rabbits and peripherial blood vessel) .
It seemed that the contraction by soedomycin and Na2HPO4 acted on smooth muscles directly.
4) On capillary permeability in mice, Na2HPO4 showed no effects, but soedomycin had a slight inhibitory tendency.
5) Antigenicity test in guinea-pig included active and passive systemic anaphylaxis, passive cutaneous anaphylaxis, reversed passive Arthus reaction and Schultz-Dale reaction.
Soedomycin and Na2HPO4 showed negative results on their antigenicity compared with positive ones of horse serum.
From these result, it was suggested that soedomycin was the drug without side effects.
