Abstract
Systemic lupus erythematosus (SLE), complicated by thrombotic thrombocytopenic purpura (TTP), has been reported in only 12 individual cases in Japan until 1979.
We experiencel a case of SLE accompanied by TTP in a 23-year-old woman.
The patient complained of arthralgia and was diagnosed as SLE, because of arthritis without deformity, LE cell, proteinuria, granular casts in urine, neuropsychic manifestation, leucopenia and thrombocytopenia.
During 4 years, she repeated the admission of hospital 4.times. She died of renal failure after showing watery diarrhea and psychic manifestation.
In autopsy, onion-skin lesions in the spleen and wire-loop lesions in the glomeruli were observed. In the kidneys, lungs and pancreas, there were multiple microthrombi in small blood vessels.
We diagnosed this case as SLE complicated by TTP.
