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Volume 41 (1981)
- Issue 6 Pages 619-
- Issue 5 Pages 481-
- Issue 4 Pages 353-
- Issue 3 Pages 227-
- Issue 2 Pages 117-
- Issue 1 Pages 1-
Volume 41, Issue 2
Displaying 1-15 of 15 articles from this issue
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[in Japanese], [in Japanese], [in Japanese]1981 Volume 41 Issue 2 Pages 117-123
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (3777K) -
[in Japanese]1981 Volume 41 Issue 2 Pages 125-128
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
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Ikuho WADA, Hajime YASUHARA1981 Volume 41 Issue 2 Pages 129-136
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of β-adrenergic blocking drugs (β-blockers) on monoamine oxidase (MAO) and their membrane stabilizing and local anesthetic effects were studied. MAO activities were determined by the radioisotopic assay using 14C-5-hydroxytryptamine (5-HT) 14C-β.phenylethylamine (β-PEA) as substrates. Inhibition of hypotonic hemolysis of rat erythrocytes was measured as hemoglobin concentration in the supernatant. Local anesthetic effects were tested by the rabbit's cornea method. β-blockers at concentrations of 1×10-4M to 1×10-3M except for atenolol inhibited MAO in rat brain homogenate and liver mitochondria with 5-HT as substrate. The order of potency was propranolol> pindolol>oxpreonolol. Propranolol and pindolol inhibited 5-HT oxidation much more than β-PEA oxidation. Inhibition of MAO activity by β-blockers was reversible. Propranolol inhibited 5-HT oxidation by liver mitochondrial MAO competitively while pindolol and oxprenolol inhibited 5-HT oxidation non-competitively. Membrane stabilizing effects of β-blockers except for oxprenolol on erythrocytes were observed from concentration of 6×10-5M. The order of potency was propranolol>pindolol>atenolol. Local anesthetic effects of β-blockers on cornea were observed from concentration of 2×10-4M. The surface anesthetic potency of β-blockers was higher order of propranolol>pindolol>oxpren-olol>atenolol. These results suggest that inhibitions of MAO (type A) activities by β-blockers are correlated to their local anesthetic effects. Possible mechanism of hypotensive effect of β-blockers will be discussed in this respect.View full abstractDownload PDF (930K) -
Hiroyuki MATSUO1981 Volume 41 Issue 2 Pages 137-145
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of tricyclic drugs, imspramine (IM), desipramine (DMI), chlorimipramine (CIM) and chlorpromazine (CPZ) on isolated rat hepatocytes, crude mitochondrial fraction and erythrocytes were studied at various concentrations. Loss of intracellular enzyme into surrounding media was used to quantitate cytotoxic effects. Inhibition of hypotonic hemolysis of rat erythrocytes was measured as hemoglobin concentration.
The potency of leakage of total GOT (t-GOT) and mitochondrial GOT (m-GOT) was CPZ>CIM>DMI>IM. All drugs caused decrease in GPT leakage at 1 × 10-4M but CPZ and CIM caused increase in GPT leakage at 4 × 10-4M. The potency of leakage of LDH was CPZ>CIM>DMI>IM. All drugs caused decrease in enzyme leakage with decreasing incubation temperature. The potency of leakage of β-glucuronidase from crude mitochondrial fraction was CPZ>CIM>DMI>IM.
The ability of various drugs to inhibit the hypotonic hemolysis is considered to represent a membrane stabilizing effects. Maximum inhibition of the hypotonic hemolysis was observed at a concentration of 1 × 10-4M in CPZ and CIM, and 4 × 10-4M in DMI and IM. The concentration of drugs causing enzyme leakage from hepatocytes were coincided with the concentration causing hemolysis. The rank order of surface activity was the same as that of hepatotoxicity and hemolysis in vitro. These results suggest that the differences in membrane damage produced by tricyclic drugs may be related to surface activity which in turn may determine the extent of adsoption onto cell membranes.View full abstractDownload PDF (1102K) -
I: MECHANISM OF ACUPUNCTURE-MOXIBUSTION'S EFFECT ON LOCAL PAIN ESTIMATED FROM SKIN AND MUSCLE TEMPERATURES AND VOLUME PULSE WAVEHaruto KINOSHITA1981 Volume 41 Issue 2 Pages 147-156
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn order to clarify the mechanism of the effect of acupuncture-moxibustion therapy for local pain, the skin and muscular temperatures at the site of pain in patients exhibiting sciatica-like symptoms were measured by thermocouple thermometer before and after acupuncture-moxibustion therapy on acupuncture points.
Comparing the temperatures at the site of pain with those in the corresponding area on the contralateral side of the body, both skin and muscular temperatures were found to have a lower temperature at the site of pain than the corresponding normal sits in the contralateral side, however following acupuncture treatment therapy, the temperatures rose to near the values of the contralateral side.
The volume pulse wave heights in the painful area, measured by reflex type plethysmography, increased with the administration of acupuncture-moxibustion therapy and with returning the skin temperatures to the values of the contralateral side.
The volume pulse wave heights on the tips of the toes, measured by transparent type plethysmography, decreased when the lower limbs were raised to the level at which pain was felt, however following acupuncture-moxibustion therapy the rate of decrease in plethysmography reduced even when the lower limbs were raised.
When acupuncture was applied to the aupuncture points or to the tender muscle in patients, in whom due to severe tension of the scalene muscle blood circulation at the tips of the toes was suspended with movement of the head. When muccle relaxants were administered, similar effects were obtained,
From the above results it can be assumed that acupuncture-moxibustion therapy served to restore the decreased circulation, which is the cause of pain due to the increased muscular tonus.View full abstractDownload PDF (5853K) -
Haruhiko ITO1981 Volume 41 Issue 2 Pages 157-164
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe central mechanism of animal hypnosis was investigated in correlation with that of acupuncture analgesia by measuring the duration of animal hypnosis (DAH) induced by inversion of rabbits.
DAH and analgesia during inversion were not influenced by naloxone, an opiate antagonist. DAH was prolonged by stimulation of the dorsal periaqueductal central gray or by administration of morphine and this effect was abolished by naloxone or by the lesion of acupuncture afferent pathway such as the lateral septum or the anterior hypothalamus.
DAH was shortened by methysergide, a serotonergic blocker, and it was extremely prolonged by tetrabenazine, a monoamine depletor.
The lesion of lateral portion of the fourth ventricle in the dorsal pons shortened DAH.
From these results, it was concluded that the central mechanism of animal hypnosis was different from that of acupuncture analgesia, but was modified by acupuncture afferent pathways and hence by endogenous morphiue like factor which was liberated by activation of acupuncture afferent pathway.View full abstractDownload PDF (6145K) -
Haruhiko ITO1981 Volume 41 Issue 2 Pages 165-170
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe involvement of the dopaminergic system in acupuncture and morphine analgesia, measured by tail-flick test in rats has been investigated by observing the changes in acupuncture analgesia after treatment of a dopaminergic blocker, pimozide.
Acupuncture analgesia was completely antagonized by pimozide (4 mg/kg), while pimozide had no influence on the threshold of pain. Antagonistic action of pimozide on acupuncture analgesia was dose dependence.
Morphine analgesia was also completely antagonized by pimozide, and pimozide antagonized stimulation-produced analgesia caused by stimulation of acupuncture afferent pathways such as the dorsal periaqueductal central gray (PAG), the lateral septum and the anterior hypothalamus.
Pimozide did not antagonize the analgesia produced by stimulation of the ventral PAG which is one of the origins of acupuncture efferent pathways.
These data indicate that the dopaminergic system is involved in acupuncture afferent pathways.View full abstractDownload PDF (3323K) -
Haruhiko ITO, Terumichi MIZUNO, Masahiko FUJISHITA1981 Volume 41 Issue 2 Pages 171-174
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEEG frequency analysed changes caused by dorsal periaqueductal central gray (dorsal PAG) stimulation in rabbits were compared to EEG frequency analysed changes by acupuncture stimulation to confirm the nature of dorsal PAG as an acupuncture afferent pathway.
After the latent period, θ element was decreased and, later, δ element was increased by dorsal PAG stimulation. Such changes persisted for a while after termination of PAG stimulation (after-effect) . These EEG changes were quite similar to those caused by acupuncture stimulation.
The tendencies towards a reduced latent period and an increaed after-effect were increased by increasing stimulus intensity.
Stimulation of regions other than the acupuncture afferent pathway caused no EEG changes.
These data indicate that the dorsal PAG is an acupuncture afferent pathway region.View full abstractDownload PDF (2946K) -
Yoshihisa HAYASHI1981 Volume 41 Issue 2 Pages 175-184
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSpecific IgG and IgE antibodies were determined in 101 asthmatic children during the course of immunotherapy with allergen extracts of mite, silk and alternaria. The results were studied in relation to the clinical improvement of the patients.
In each antigen IgG antibodies showed high levels when the concentration of the extracts were great enough to reach maintenance dose, and the duration of the therapy was sufficiently long. No significant changes could be seen in respect to IgE antibodies.
IgG antibodies showed remarkably higher levels in the group of patients reporting excellent clinical effect, while they showed lower levels in the “improving” group, “unchanged” or “worse” group and “controlled ”, group as well.
IgG antibodies increased about six months after initiation of immunotherapy.
No significant correlations could be found between IgE antibodies and the clinical symptoms of the patients.View full abstractDownload PDF (1085K) -
Akira MATSUMOTO, Keiko KOBAYASHI, Namika TANAKA, Shoji YAMADA, Tsuneko ...1981 Volume 41 Issue 2 Pages 185-191
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe analysis of calcium (Ca) and strontium (Sr) elements in epiphyseal cartilage plate (ECP) and trabeculae of bone of rat-tibiae given SrCO3 was done by using an electron probe X-ray microanalyser (EPMA) and a laser microspectral analyser (LMA) .
In the ECP of both control and low Ca rats, both Ca and Sr elements were not found by EPMA. Ca elements were detected by LMA, but Sr elements were not detected by LMA. In the ECP of rat given SrCO3, both Ca and Sr elements were found not by EPMA but by LMA. In the trabeculae of bone of both control and low Ca rats, Ca elements were found, but Sr elements were not shown by EPMA. In the trabeculae of bone of rat given SrCO3, both Ca and Sr elements which distributed uniformly in trabeculae of bone were found by EPMA. From these facts, it was suggested that the analytical limits for some biological important elements of LMA were lower than that of EPMA, and Sr invaded epiphyseal cartilage plate and disturbed endochondral ossification.View full abstractDownload PDF (5807K) -
Toru KATO, Masao NEGISHI1981 Volume 41 Issue 2 Pages 193-201
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt has recently been proven that D-penicillamine (D-Pc) is an effective agent in the management of patients with rheumatoid arthritis.
D-Pc was shown to have an inhibitory effect on the formation of antibodies against sheep red blood cells (SRBC) and, more specifically, against antibody-producing cells after long-term treatment of rats before inoculation with SRBC. D-Pc was also shown to act inhibitorily on adjuvant arthritis in rats and DNCB contact dermatitis in guineapigs. It was suggested that the mechanism of action of D-Pc on rheumatoid arthritis was the inhibitory effects of D-Pc on both humoral and cellular immunity.View full abstractDownload PDF (1077K) -
Fumio SHINOHARA, Shin INOUE, Harumichi FUJIMOTO, Masatoshi KAWAMURA, T ...1981 Volume 41 Issue 2 Pages 203-206
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTuberculous aortitis is a rare complication of tuberculosis in which the aorta causes ruptures, in most cases. We recently encountered a case of tuberculous aorto-oesophageal fistula with false aneurysm formation. The patient was a 38-year-old female and died of massive haematemesis. An aorto-oesophageal fistula was enpendered by direct extension of tuberculous inflammation from mediastinal lymph nodes. Tuberculous foci were found in the lungs, liver, spleen, lymph nodes and kidneys.
The present case might be in the category of post-primary cryptic disseminated tuberculousis.View full abstractDownload PDF (4144K) -
Tatsuaki NOZU, Makoto ISHII, Kazue KIKUCHI, Atsuyo HAGINOYA, Norihiro ...1981 Volume 41 Issue 2 Pages 207-212
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 26 year-old man, a native of Tokyo, was diagnosed to have hypochromic microcytic anemia at the time medical examination. The erythrocyte count was 569× 104 per cmm, hemoglobin 12.3 g/dl, hematocritt 37.4% (MCV 65μ3, MCH 21.6 γγ) . The reticulocyte count was 16 %. Anisocytosis, poikilocytosis, and target cells were seen in peripheral blood. Serum iron was 129 μg/dl, total iron binding capacity 348μg/dl, ferritin 320 ng/ml. Hemoglobin F and A2 were significantly elevated. Red cell fragility with coil planet centrifuge was markedly decreased (HEP 48 mOsm, HSP 90 mOsm) . Bone marrow aspiration revealed erythroid hyperplasia.
As a result of the examination of 12 of his family members, blood data of 5 persons including his mother, a native of Shizuoka, were similar to that of propositus. The diagnosis of β-halassemia minor, transmitted from the mother's side, was made.
We had studied only 46 family trees in Japan before our report.View full abstractDownload PDF (1811K) -
Miki KUSHIMA, Harumichi FUJIMOTO, Kazuo KONDO, Akira SHIOKAWA, Yoshihi ...1981 Volume 41 Issue 2 Pages 213-217
Published: April 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSystemic lupus erythematosus (SLE), complicated by thrombotic thrombocytopenic purpura (TTP), has been reported in only 12 individual cases in Japan until 1979.
We experiencel a case of SLE accompanied by TTP in a 23-year-old woman.
The patient complained of arthralgia and was diagnosed as SLE, because of arthritis without deformity, LE cell, proteinuria, granular casts in urine, neuropsychic manifestation, leucopenia and thrombocytopenia.
During 4 years, she repeated the admission of hospital 4.times. She died of renal failure after showing watery diarrhea and psychic manifestation.
In autopsy, onion-skin lesions in the spleen and wire-loop lesions in the glomeruli were observed. In the kidneys, lungs and pancreas, there were multiple microthrombi in small blood vessels.
We diagnosed this case as SLE complicated by TTP.View full abstractDownload PDF (2819K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1981 Volume 41 Issue 2 Pages 219-225
Published: April 28, 1981
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSDownload PDF (998K)
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