Abstract
We have investigated the anti-inflammatory and wound-healing effects, as well as the stabilizing effects on erythrocytes membrane and lysomsomal fraction in liver of synthetic diisopropyl 1, 3-dithiol-2-ylidene malonate (malotilate), by oral administration and obtained the following results: Malotilate showed an inhibitory effect on enhanced vascular permeability induced in mice by the intraperitoneal infusion of acetic acid or bradykinin. Malotilate (250 mg/kg. p.o.) showed equal inhibitory effect as aminopyrine (100 mg/kg, p.o.) to the enhanced vascular permeability induced by acetic acid. When tested for anti-edematous action by carrageenin and formalin-induced edema methods, malotilate proved to exert anti-edematous action. When its effect on granulation was tested by both the formalin-filter paper pellet method and the agar implantation method, malotilate proved to exert an apparent promotive action on granulation. Furthermore, histological examination also verified the same positive and promotive effects on granulation. Malotilate apparently promoted the wound-diminishing rate in the round skin defective wound (20 mm in diameter) induced on the back region of rats. Again, histological examination also verified its positive and promotive effect on the wound-diminishing process. When tested for stabilizing effect on erythrocytes membrane, malotilate of 1×10-5 proved equal effect as aspirin of 5×10-4M to the stabilizing effect on erythrocytes membrane with heat-induced hemolysis method. Malotialte caused increase in β-glucronidase leakage on lysomsomal fraction in rat liver at 5×10-4M, but acid phosphatase leakage was not increased at 1×10-6M to 1×10-2M.
