Abstract
Recently, an increased number of systemic fungal infections has been seen in cases of acute myelogeneous leukemia. A 35-year-old woman was admitted to our hospital because of fever in February, 1978. She was diagnosed as having AML by the presence of leukemic cells in peripheral blood and on the basis of bone marrow findings. She was treated with daunomycin, cytosine arabinoside, prednisolone, 6MP, MTX and other drugs for 18 months after admission. Complete remission was induced, but, in August of 1979, she was readmitted due to relapse of AML and fever. Chest X-ray revealed cardiomegaly and an abnormal shadow in the right upper lobes. ECG revealed ST elevation and low voltage, but no changes in myocardial enzyme level were observed. She died of respiratory distress and heart failure in September, 1979. Autopsy revealed Aspergillus myocarditis and pericarditis (pancarditis) with large mural thrombus by Aspergillus, pulmonary infarctions with organized thrombi of both pulmonary arteries and pulmonary Aspergillosis. Aspergillus infections were also observed in the kidney, spleen, stomach and esophagus.
