Abstract
Semi-Alkaline-Proteinase, Seaprose-S (SAP), produced by Asperigllus mulleus, was investigated anti-inflammation, using Carrgeenan's phlogogenic action to the experimental sciatic perineuritis of rats. Carrageenan (CRG) has been shown dramatic model of pen-and/or neuritis on the sciatic nerve at 0.05% of concentration that increase lymphotic leucocyte (lymphocytosis) arround the nerve tissues, fragility of neurolemma membrane and neurotelangiectodic findings, etc. Results of SAP treatment for anti-CRG effects showed that pre-administered group with 500mg/kg (p. o.) inhibited 70% of 0.05% CRC's phlogogenic action, and SAP treatmented group with antibiotics Cefamezin (CEZ) showed complete inhibition, while the mechanisms of these anti-CRG effects of SAP (and/or SAP+CEZ) have not known yet. Therefore SAP might be expected to have clinical application in the relief of the phlogosis, including neuritis, perineuritis and so on.
