PHARMACOLOGICAL STUDIES ON PANAX NOTOGINSENG EXTRACT (HK302)

III. INFLUENCE OF BLOOD COAGULATION SYSTEM IN RATS

Abstract

We investigated the effect of HK302 (freezed-dried powder of ethanol extract from roasted Panax Notoginseng) on the blood coagulation system of male wistar strain rats. The weak reduction of whole-blood coagulation time and plasma recalcification time were induced by the pre-administration of HK302 for 60 minutes per-orally. However, HK302 didn't elicite any influence on thrombin time of the rats. The above indicated that HK302 had somewhat difference on the activity to blood coagulation system compared to that of raw Panax Notoginseng.