Abstract
Relationship between mean platelet volume (MPV) and platelet count (Pit) vary inversely and non-linearly under normal bone marrow function, and the MPV-Plt relationship differs markedly according to whether the condition of decreased thrombopoiesis in myelosuppression. The purposes of this study were 1) to obtain a nomogram of MPV-Plt in normal subjects in pediatric age group, 2) to evaluate the marrow function in pediatric patients with myelosuppression following myelosuppressive regimen for malignant solid tumor, and 3) to develope the appropriate clinical assessment for damaged marrow. The nomogram obtained in 135 normal subjects was classified into 5 areas : Area A-B defined as Plt over 100, 000 per cubic milliliter MPV within its normal range, compatible for normal marrow; Area C, as Plt over 100, 000 per cubic milliliter despite MPV lower than nomogram range, suggesting mild suppression; Area D, as marked decline in both MPV and Plt, suggesting obvious myelosuppression at its lowest; and Area E, as MPV over 9.5 fl and Plt less than 100, 000 per cubic milliliter, compatible for recovery from myelosuppression. This assessment for suppressed marrow function was useful for making clinical decision for supportive therapy and/or modification of on-going treatment protocol.
