Abstract
Effects of Sasa senanensis Rehder extract (SE) on inflammatory reaction and phagocytic activity were studied in experimental animals. SE were extracted from Sasa senanensis Rehder by alkaline hydrolysis. At doses of 10 and 20m1/kg (p.o.), SE slightly inhibited the increase of vascular permeability induced by acetic acid in mice. There was a significant antiedematous effect of SE on formalin-induced hind paw edema in rats 3 hr after oral administration of 5 ml/kg. On the other hand, SE increased hind paw edema induced by carrageenin. No apparent effect of SE on granuloma formation induced by formalin-filter paper pellet and agar implantation was observed by Hematoxyline-Eosine or Azan-Mallory's stain. No difference was found between control and SE treated rats in the determination of weights of granuloma formed around paper pellets and agar.
The effect of SE on phagocytic activity of the mouse reticuloendothelial system was studied by the carbon clearance method. The K index and a index were increased from 3 to 5 hr by a single administration of SE (0.2 ml/body, p.o.) . This result suggested that a single administration of SE enhances phagocytic activity. However, no change of phagocytic activity was found after multiple administrations of SE.
