Abstract
We measured postheparin lipolytic activity (PHLA) in diabetic patients with nephropathy, without nephropathy and in nephrotics to study its relation to renal function, serum albumin and HDL-cholesterol; and to the insulin secretory function in diabetics. The effects of apoprotein and abnormality of VLDL, which may be a cause of abnormality of lipoprotein lipase (LPL) activity, were also studied. 1) For diabetics with nephropathy, PHLA tended to be positively correlated, but not significantly, with insulin secretion. PHLA was positively correlated with serum albumin (r=0.579, p<0.05) . 2) PHLA was remarkably reduced in nephrotics (p<0.001) . 3) A test in which postheparin plasma from a normal subject was added to a VLDL fraction revealed reduction of LPL activity in nephrotics (p<0.01) . 4) In a test to add apo VLDL for diabetics with nephropathy and nephrotics, reduction of LPL activity was recognized in nephrotics compared to controls (p<0.001) . Also, a comparison of the rate of increase in LPL activity, showed a low value for apo VLDL in diabetics with nephropathy and nephrotics (p<0.05 for both groups) . The results indicated possible abnormality in the apoprotein structure of apo VLDL as well as in the composition in diabetics with nephropathy, especially in cases of nephrotic syndrome and nephrotics.
