Abstract
The purpose of this study was to determine the effects of superimposed, jet oscillated ventilation (SOV) on 4 types of experimental acute lung injury, such as pulmonary edema, RDS, methacholine induced bronchial constriction, and histamine induced bronchial constriction. The PaO2 increased significantly only in the group with bronchoconstriction by methacholine when the ventilation support was changed from conventional mechanical ventiation (CMV) to superimposed 10 Hz-jet oscillation (SOV) during expiration. There was no significant difference in PaO2 between CMV and SOV in the three remaining subjects. Though Pa CO2 decreased easily under SOV in all injured lung groups compared to CMV, the respiratory phase in which jet oscillation decrease PaCO2 was not the same in injured lungs. There was no significant change in circulation between CMV and SOV in all subjects. The author conclude that SOV is better for gas exchange when pulmonary failure is the result of bronchoconstriction (induced by methacholine) .
