Abstract
A survey was made of the side effects of antiepileptic agents used for 221 cases over 10 years. They were examined at Showa University Hospital during the year 1987 to 1988. Nervous disorders were observed in 92 cases, dermal disorders in 92, digestive disorders in 182, hematological disorders in 59 and osteo-metabolic disorders were seen in 42 cases. There was a significantly high possibility of combined troubles in the nerves and skin, as well as blood- and osteo-metabolism. Nervous disorders occurred significatly often in cases of symptomatic general epilepsy, or thse complicated by brain-damage, or mental retardation, or as initial side effects in cases less than 10 years old. Dermal disorders occurred significantly often in symptomatic general epilepsy, or in cases complicated by mental retardation as the existing problem. The use of PB and DPH at the time of the occurrence of the problem, produced more than 70% of the nervous and dermal disorder side effects. However, the original drugs were not clearly indentified. Among the nervous and dermal disorders, whether or not they belonged to symptomatic general epilepsy, anamnesis of brain damage in nursing-babies or mental retardation, there was no significat differance in the dosage and number of drugs at the occurrence of the side effects. There was a high possibility of overlap between nervous and dermal disorders, so it is suggested that the occurrence of side effects might depend greatly on individual factors.
