Abstract
We examined creatine kinase BB (CK-BB) isoenzyme and neuron-specific enolase (NSE) levels by radioimmunoassay in cerebrospinal fluid (CSF) of 50 children with neurologic diseases. Especially, we repeatedly examined 17 children with meningitis, and obtained the following results : (1) In patients with meningitis and CNS Lupus, CK-BB levels in CSF were elevated. NSE levels in CSF were also elevated in patients with meningitis. (2) In 4 patients with bacterial meningitis, CK-BB levels in CSF were elevated during the active state, but soon became normal in convalescence. However NSE levels in CSF were not elevated significantly more than in the control group, in any state. (3) In 13 patients with aseptic meningitis, CK-BB levels in CSF were also elevated in the active state, but soon became normal. On the other hand, NSE levels in CSF were not greately elevated in the acute state, but increased slightly in the convalescent state, in many cases. These results suggest that CK-BB in CSF might be a useful marker of neurologic disease.
