Abstract
Effects of dibutyryl cyclic AMP (DBcAMP) on the respiratory, circulatory, endocrine and metabolic systems were studied in adult mongrel dogs. Dogs were infused with 0.6mg/kg/min DBcAMP for 120 minutes. During DBcAMP infusion, positive inotropic and chronotropic effects, and dilatation of peripheral vassels were observed. These effects diminished slowly after the infusion of DBcAMP was stopped. DBcAMP did not affect pulmonary circulation or blood gas data as much as expected. Plasma levels of epinephrine norepinephrine, and renin activity increased significantly. Despite increases of these hormone, systemic vascular resistance decreased remarkably and hemodynamic activity was not affected. Bloodlevels of glucose, insulin and glucagon, and the insulin/glucose ratio all increased significantly. Non-esterified fatty acids decreased significantly. These findings indicate that DBcAMP drives energy metabolism towards enhancement of glucose utilization thereby improving energy metabolism. Blood lactate levels and L/P did not change significantly, thus DBcAMP apparently did not affect peripheral circulation.
