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Volume 52 (1992)
- Issue 6 Pages 595-
- Issue 5 Pages 461-
- Issue 4 Pages 369-
- Issue 3 Pages 241-
- Issue 2 Pages 123-
- Issue 1 Pages 1-
Volume 52, Issue 2
Displaying 1-15 of 15 articles from this issue
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Kenji SHIDA, Masao KOBORI, Hideru NEGISHI, Akiyoshi HOSOYAMADA1992 Volume 52 Issue 2 Pages 123-128
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEffects of dibutyryl cyclic AMP (DBcAMP) on the respiratory, circulatory, endocrine and metabolic systems were studied in adult mongrel dogs. Dogs were infused with 0.6mg/kg/min DBcAMP for 120 minutes. During DBcAMP infusion, positive inotropic and chronotropic effects, and dilatation of peripheral vassels were observed. These effects diminished slowly after the infusion of DBcAMP was stopped. DBcAMP did not affect pulmonary circulation or blood gas data as much as expected. Plasma levels of epinephrine norepinephrine, and renin activity increased significantly. Despite increases of these hormone, systemic vascular resistance decreased remarkably and hemodynamic activity was not affected. Bloodlevels of glucose, insulin and glucagon, and the insulin/glucose ratio all increased significantly. Non-esterified fatty acids decreased significantly. These findings indicate that DBcAMP drives energy metabolism towards enhancement of glucose utilization thereby improving energy metabolism. Blood lactate levels and L/P did not change significantly, thus DBcAMP apparently did not affect peripheral circulation.View full abstractDownload PDF (639K) -
Akihiro YOSHIDA1992 Volume 52 Issue 2 Pages 129-140
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe prolabium is an anatomical element which forms the free margin of the upper lip and greatly contributes to the creation of the impression of individual facial features. In this study, the author analyzed the morphology of the prolabium at rest in 100 healthy young Japanese men and women (mean ages : male, 9.6 years ; female, 26.8 years), and compared the results with previous statisitical data. At the same time, angles formed by the main components of the circumference of the prolabium of the upper lip, which are important for morphological classification, were also measured. After reference points established by the author were directly measured on standard photographs of upper lips, mean values and standard deviations were calculated, and differences between men and women, and between ages, and correlations between parameters were determined. The internal oblique margin of the upper vermilion and the width of the rima oris were significantly larger in men (p<0.01), whereas the beta and gamma angles were significantly larger in women (p<0.05) . There were no statistically significant differences in other parameters, including the height of the upper vermilion, the maximum height of the upper vermilion, and alpha and delta angles. There were no statistically significant differences between ages in the twenties and in the thirties. There was marked correlation between the height of the upper vermilion and the maximum height of the upper vermilion in both men and women, suggesting that comparison of the individual thickness of the prolabium of the upper lip can be based on either one of these 2 parameters. However, the maximum height of the upper vermilion seemed to be more relevant to the evaluation of the thickness of the prolabium of the upper lip. Both men and women showed correlation between alpha and beta angles; namely, the larger the angle alpha, the larger the angle beta, making the margin of the prolabium less clear. From these results, it was thought that young Japanese tend to give the impression that their prolabium have steep lateral margins and thick median regions because their alpha angle was larger while their beta and gamma angles were smaller than those of women. In contrast, young Japanese women appeared to have prolabium of the upper lip with gentle-slope and soft lateral margin, causing the impression of thin median region.View full abstractDownload PDF (1031K) -
Yoshiaki TAKEUCHI, Fumihiko NOZU, Ikuta NAKANO, Shigeki TANAKA, Yoshio ...1992 Volume 52 Issue 2 Pages 141-147
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTo investigate the regulation of rat pancreatic secretion, we examined upper intestinal perfusion in conscious rats during diversion of bile-pancreatic juice (BPJ) . Diversion of BPJ from the upper intestine greatly increased pancreatic secretion associated with the elevation of plasma CCK. From this result, we hypothesized that a trypsin sensitive CCK releasing factor in the upper intestinal lumen, and that diversion of BPJ retains its activity from protease digestion. We perfused the upper intestine with phosphate buffer saline (PBS) and observed pancreatic volume, protein, bicarbonate output, and plasma CCK. Washing the upper intestine with PBS decreased all pancreatic secretion and plasma CCK. From this result, we believe that an intraluminal CCK releasing factor regulates CCK release, and our putative CCK releasing factor is different from the monitor peptide that exists in pancreatic juice.View full abstractDownload PDF (770K) -
Yasuyoshi TOSA1992 Volume 52 Issue 2 Pages 148-157
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe nasal cavity volume in 69 healthy volunteers from 8 to 23 years old (17 males and 52 females) was studied using magnetic resonance imaging (MRI) . Merits of MRI such as 1) no radiation exposure, 2) less artifact due to bone and air and 3) measurement of intravascular blood flow; and demerits such as 1) contraindication in users of heart pace-makers or maquetic clips, 2) contraindication in people with claustrophobia and 3) influence of environmental magnetic fields must be considered. A Magnetom M10 (Siemens), a superconduction device with 1.0 Tesla magnetic flux density was used. Enhanced patterns of T1, and pulse lines were photographed at 600 msec TR (repetition time) and 19 msec TE (echo time) using SE (spin echo) and short SE (spine echo), and 3 or 4 mm slices. Photographs were made of the piriform aperture, choana, superior-middle-inferior concha including the nasal meatus, the frontal sinus, maxillary sinus, cribriform plate, and upper surface of the palate. The line connecting the maximum depression point in the nasal root and the pontomedullary junction was selected by sagittal median section, because this corresponds well with the CM (canthomeatal) line which is useful in CT (computed tomography) . The transverse section of the nasal cavity volume was traced by display console with an accessory MRI device and calculated by integration of the slice width. The increase of height and body weight neared a plateau at almost 16 years, whereas increase of nasal cavity volume continued until about 20 years. Piason's coefficient of correlation and regression line were significant. There were no significant differences in these parameters between male and female groups. Comparatively strong correlation between nasal cavity volume, and age, height and body weight was statistically evident.View full abstractDownload PDF (3915K) -
Yasuo NOZAKI, Kazuya UTAHASHI, Taizi KAWADA, Ikuta NAKANO, Hitoshi FUN ...1992 Volume 52 Issue 2 Pages 158-163
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is generally accepted that elastase is important to elastin metabolism in arterial walls, but there are few reports of serum elastase level in arteriosclerosis. We investigated relations between serum pancreatic enzymes including elastase I and lipids as a risk factor of arteriosclerosis. Elastase I was correlated well with the atherogenic index (AI) calculated from total and HDL-cholesterol values, and there was slight negative-correlation between HDL-cholesterol and serum pancreatic amylase or lipase. In the high risk group for arteriosclerosis (AI 3), or the aged (above 65 years) group, serum pancreatic enzymes including elastase I were slightly, but not significantly high. Study of distribution of elastase I with age showed that serum elastase I levels gradually increase with age above 40 years. The results suggest that serum pancreatic enzyme levels, especially elastase I, may reflect arteriosclerotic changes in kidney and pancreas, so we must pay attention to age and degree of arteriosclerosis when we assess the serum elastase I level.View full abstractDownload PDF (611K) -
Misao SOMEYA1992 Volume 52 Issue 2 Pages 164-177
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDual energy X-ray absorptiometry (Hologic QDR-1000) was used to quantitatively analyze the diagnosis and prevention of osteoporosis. Results were as follows: The peak BMD of the spine appeared in the twenties in normal men and in the thirties in normal women. There was acceleration of bone loss in the 50 to 60 year age bracket (premenopause and postmenopause) in normal women. On the contrary, the peak BMD of the femoral neck in normal men and women appeared in the twenties after which it decreased slightly with age. Comparison showed that the femoral neck BMD of normal women was lower than that of men throughout all ages. The fracture threshold, 0.756g/cm2 for the spine, was obtained by scanning 73 females with spinal fractures, the mean BMDs for L2-L4 at the 90th percentile level were used as the fracture threshold. The fracture threshold of femoral neck fracture was the femoral proximal BMD of the 9th decile. Classification by the Public Welfare Silver Science Group's method and by the Singh index, except Grades I, II, and III, revealed a difference; as the severity of bone atrophy advanced, BMD tended to decrease. The percent reduction of BMD ten years after premenopause was 21.0% in the spine and 13.2% in the femoral neck. Correlation between BMD and weight, weight/height ratio, BODY MASS INDEX was significant. No correlation between BMD and bone metabolism factors in the blood was found in 50 osteoporotic petients. The results of this study showed that dual energy X-ray absorptiometry (Hologic QDR-1000) can objectively diagnose and suggest measures for prevention of osteoporosis, and is clinically useful.View full abstractDownload PDF (4855K) -
—RELATION OF LAMININ POSITIVITY AND VENOUS INVASION TO LIVER METASTASIS—Tohru SATOH1992 Volume 52 Issue 2 Pages 178-189
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWell-defined basement membrane laminin (LN) was seen in 93 progressive colorectal carcinomas stained by immunohistological methods (LN and VB-LN double stain) using 10% formalin fixed specimens to clarify relations between LN positivity of the primary tumors and their liver metastasis. Among these 93 colorectal carcinoma cases, 22 were affected by simultaneous liver metastasis (H (+) group), and LN staining was positive in 48 (51.6%) . Positive LN staining was found in 17 liver metastasis cases (77.3%) of H (+), and 31 cases (43.7%) of H (-), a statistically significant difference (P<0.01) . There was no correlation between LN staining and macroscopic appearance, histologic type, depth of infiltration, or v, ly, and n factors. In LN staining of primary lesions, positive rates of intravenous cancer nests (vLN) were 54.5% of H (+) and 8.2% of H (-), which were significantly different (P<0.01) . There was correlation between LN positivity of primary lesion and vLN. Liver metastasis was recognized in more than 80% of the patients that were proved v2-3, and simultaneously LN staining or vLN positive. Also, among ssv (+) cases, more patients with liver metastasis were positive for both LN and vLN than were patients without metastasis (P<0.05) . These data indicate that LN and vLN positive staining of primary lesions might appear in a group at high risk for liver metastasis, and investigations of simultaneous LN staining and venous invasion could be useful for predicting liver metastasis. VB-LN double staining, by which it is possible to examine both LN staining and v studies from the same specimen, could be a viable method.View full abstractDownload PDF (6492K) -
—AN IMMUNOHISTOCHEMICAL STUDY USING CONFOCAL SCANNING LASERMICROSCOPY—Tomoyuki UMEDA, Keiichiro YONEYAMA, Tomoko TACHIBANA, Yoshio HATTA1992 Volume 52 Issue 2 Pages 190-196
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSChanges in the expression of gap junction protein and their relation to DNA synthesis of hepatocytes in regenerating rat liver were examined immunohistochemically with monoclonal connexin 32 antibody. In normal rats, stringlike immunostaining (S-type) was found along the lateral membranes of the hepatic cells. The number of S-type decreased in galactosamine induced liver injury, and the number of large round immunostaining particles (L-type) observed in the cytosol of hepatic cells increased. During the healing of hepatic cells from damage induced by galactosamine, the number of L-type spots were increased slightly for 24-96 hours, and the maximum DNA synthesis was observed after 96 hours. S-type spots gradually returned to twothirds of the normal level 196 hrs after galactosamine injection, and this was accompanied by the decrease of L type particles. The results suggest that alteration of liver gap junctions induced by galactosamine was not related to cell proliferation, unlike previously reported alteration after partial hepatectomy.View full abstractDownload PDF (6792K) -
—ESPECIALLY THE INNERVATION OF VIP NEURONS—Hisataka SHIGA, Seiji SHIODA, Yasumitsu NAKAI1992 Volume 52 Issue 2 Pages 197-206
Published: April 28, 1992
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSDistribution of nerve fibers containing catecholamine, 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA) and neuropeptides such as vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and substance P (SP) ; and interactions between these nerve fibers and glandular cells, myoepithelial cells, or blood vessels in the submandibular gland of the rat were examined by means of light and electron microscopic immunohistochemistry using tyrosine hydroxylase (TH), 5-HT, GABA, VIP, NPY and SP antisera. TH-, 5-HT-, GABA-, VIP-, NPY-, and SP-like immunoreactive nerve fibers were distributed around the acini, the excretory ducts and the blood vessels in the interstitial tissue. VIP-like immunoreactive nerve terminals penetrating into the acinus, were found to make synaptic contacts with both seromucous and mucous glandular cells. In the interstitial tissue, TH-like immunoreactive nerve fibers were found, in part, to make synaptic contact with the smooth muscle cells surrounding blood vessels. These findings suggest that VIP-containing neurons may be important in salivary secretion, and catecholamine- and NPY-containing neurons may contribute to the control of blood flow.View full abstractDownload PDF (13802K) -
Mitsutaka KADOKURA, Noboru TANIO, Makoto NONAKA, Shigeru YAMAMOTO, Tak ...1992 Volume 52 Issue 2 Pages 207-211
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDetection and clinical results of treatment for lung cancer have not been satisfactory. During the past 5 years, 186 patients were treated for lung cancer. Of these 186 patients, 64 were detected by mass surveys for lung cancer, 99 were detected by complaints, and 23 were detected by chance. Three cases of advanced lung cancer were reported that were referred to as “Doctor's Delay”. These were detected through chest roentgenograms. Of these 3 patients, one was detected by atelectasis of the right lower lung field in a chest roentgenogram. The roentgenogram of another had been diagnosed as lung tuberculosis, and the third was diagnosed as normal. They were narrowly treated by surgical resection. Pathological diagnoses of these cases were advanced lung cancer (stage IIIA) . We conclude that it is important to inspect chest roentgenograms carefully and compare them with previous studies.View full abstractDownload PDF (4629K) -
Masao KOBORI, Ken'ichiro OKAMOTO, Hitomi HIGUCHI, Ryo YATSUSHIRO, Yuta ...1992 Volume 52 Issue 2 Pages 212-215
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe studied the state of the pain clinic in Showa University Hospital from 1988 to 1990. There were 8699 nerve blocks in 1988, 10214 in 1989, and 9428 in 1990. Nerve blocks in this pain clinic were most often observed in the stellate ganglion, followed by epidural block. More than 80% of nerve blocks were these 2. Nerve block was most often observed in March. This was considered to be caused by rhinogenous allergy in this season. Moreover, nerve block due to the utilization of X-rays tended to increase, particularly with the celiac ganglion block being widely effective in cancer pain.View full abstractDownload PDF (516K) -
Kazuhiro ENOMOTO, Yuri HAYASHI, Fusae TANAKA, Junichi NIIKAWA, Keiichi ...1992 Volume 52 Issue 2 Pages 216-222
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA rare case of acute hepatitis B accompanied by acute renal failure was reported. A 46-year-old male with pyrexia, general fatigability and vomiting was transferred to our hospital because of the development of renal failure with liver injury. On physical examination, jaundice and petechiae on the lower extremitits were noticed, but consciousness was clear. High serum levels of GOT, GPT, bilirubin, BUN and creatinine, decreased prothrombin activity, and positive studies for HBs antigen and IgM HBc antibody were shown on laboratory examination and a diagnosis of acute hepatitis with renal failure was made. Encephalopathy did not develop during the clinical course and hepatic and renal injuries were improved uneventfully by hemodialysis, plasmapheresis and glucagon insulin therapy. Acute hepatitis B except fulminant hepatitis is rarely accompanied by acute renal failure and possible mechanisms are discussed.View full abstractDownload PDF (2250K) -
Yoshihiro WATANABE, Hiroki TAKEDA, Yuko KAWADA, Sigeo SHIN, Keiichiro ...1992 Volume 52 Issue 2 Pages 223-228
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case with stomal ulcer near afferent loop developing after partial gastrectomy (Billroth II) is reported. A 68-year-old male with abdominal pain and hematemesis was admitted to our hospital. Endoscopic examination on admission revealed massive fresh blood in the gastric remnant and duodenum, but did not reveal the distinct point of bleeding. A repeated examination 4 days later showed shallow ulceration and some erosion in the stoma near the afferent loop, and these lesions were assumed to be the source of the bleeding. Hyperacidity of gastric juice, stasis of bile and pancreatic juice in the afferent loop, decreased acid-neutralizing capacity of pancreatic juice, and change of acid composition in the bile were ruled out by functional and morphological examinations. Only the slight arteriosclerotic change was suggested on abdominal angiography. It was thus assumed that the ulcer in our case was induced by alcohol toxicity in the duodenal mucosa based on the disturbance of microcirculation due to arteriosclerosis.View full abstractDownload PDF (3890K) -
Yoshiaki TAKEUCHI, Tomoyuki UMEDA, Fusae TANAKA, Shuhei TAZAKI, Mitsur ...1992 Volume 52 Issue 2 Pages 229-233
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of rapid progression from acute pancreatitis to chronic calcifying pancreatitis within five years is reportd. The patient, a 23-year-old male, experienced the first attack of pancreatitis at the age of 17 after massive alcohol intake and was clinically diagnosed as acute pancreatitis. He thereafter continued alcohol abuse and attacks of pancreatitis recurred frequently. Three years after the first attack, he was diagnosed as having chronic pancreatitis by endoscopic retrograde pancreatography (ERP), and two years later, calcification developed further. Although we could not confirm whether or not acute pancreatitis, if the first attack was that, developed into chronic pancreatitis our case seemed to be rare because of the rapid progression of the pancreatitis. The total alcohol intake by our patient was a rather less than that generally accepted as the amount causing alcoholic chronic pancreatitis. Nevertheless, there was a pattern of pancreatic calcification like that observed in alcoholics. It was thus assumed that similar changes would be induced in the pancreas even by low doses of alcohol, if the patient was more sensitive to alcohol. It is therefore necessary to establish methods to differentiate etiologies of chronic pancreatitis including the assessment of individual sensitivity to ethanol, and detect changes of chronic pancreatitis that would not be shown by ERP in the early stages. If these became available, we could confirm the pathogensis in this case, and the relations between acute pancreatitis and chronic pancreatitis could be verified.View full abstractDownload PDF (3702K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1992 Volume 52 Issue 2 Pages 234-239
Published: April 28, 1992
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (672K)
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