Abstract
It is generally accepted that bradykinin plays an important role in the onset and progression of acute pancreatitis and in the development of multiple organ failure. In the present study, we examined the protective effects of Hoe 140, a new bradykinin B2receptor antagonist, on caerulein-induced pancreatitis in rats. Hoe 140 showed significant protective effects such as suppression of the increase of pancreatic wet weight and elevation of the plasma amylase level, and improvement in the histological changes in the pancreas was also observed. The elevation of plasma prolyl hydroxylase, which is an indicator of inflammation and tissue damage throughout the body, was suppressed by Hoe 140 administration. This study suggests that Hoe 140 has inhibitory effects not only on the progression of caerulein-induced acute pancreatitis but also on the tissue damage throughout the body which accompanies acute pancreatitis.
