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Volume 55, Issue 1
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[in Japanese]1995 Volume 55 Issue 1 Pages 1-5
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (614K) -
—Effect on Lipid Peroxidation in Mouse Spleen after Whole-Body Irradiation—Noriko OTSUKI1995 Volume 55 Issue 1 Pages 6-11
Published: February 28, 1995
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSWe have investigated the effects of dipyridamole, which has radioprotective effects in mice, on radiation damage in the mouse spleen. The level of thiobarbituric acid-reactive substances (TBARS) in the spleen, a measure of free radical initiated lipid peroxidation, increased significantly between 6 and 10 Gy 4 days after whole-body irradiation (p<0.05) . Also, the TBARS in the spleen increased linearly between days 2 and 10 after 9 Gy whole-body irradiation. The TBARS concentration in the spleen 4 days after irradiation was reduced significantly from 5.15±0.97nmole/mg protein to 3.76±0.35nmole/mg protein by dipyridamole treatment (1 hr before irrdiation, 2 mg i. p.) (p<0.01), but no effects were observed with 2mg i. p, dipyridamole treatment after irradiation. The weight of the spleen decreased significantly between 6 (31%) to 10 Gy (21%) 4 days after whole-body irradiation (p<0.05) . The spleen weight 2 day after 9 Gy whole-body irradiation (40.2±1.8mg) decreased significantly as compared with the control group (125.8 ± 16.8mg, p<0.01), and the decrease in spleen weight was related to the time lapse (after irradiation from 2 to 10 days) . The slight inhibition effect on the decrease of spleen weight was observed by dipyridamole treatment 2 days after 9 Gy wholebody irradiation. These results suggest that the radioprotective effects of dipyridamole are related to the inhibition of lipid peroxidation and to participation in the early phase of apoptosis in spleen cells.View full abstractDownload PDF (742K) -
Akihiro MATSUZAKI, Masaki OZAWA, Hiroaki UEDA, Shuichi EBATO, Kitaro K ...1995 Volume 55 Issue 1 Pages 12-18
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe studied the clinical significance of repetitive T wave inversion in 38 patients with initial acute anteroseptal infarction (mean age 63.0±12.1 years) who were admitted 24 hours after onset of myocardial infarction (MI) . They were divided into two groups : 19 with repetitive T wave inversion (Group A) and 19 without repetitive T wave inversion (Group B) . Regarding the incidence of preinfarction angina, no significance was found between the two groups, but in Group A new-onset-type unstable angina was higher (p<0.05), and postinfarction angina was also significantly higher (p<0.05) . The early appearance of abnormal Q wave (less than four hours after the onset of MI) was more frequent in Group A (p<0.05) . In Group A, residual stenosis of infarct-related arteries in the acute stage was severe (87.5±20.1 % vs 68.1±29.6 %, p<0.05), the filling delay was greater and the collaterals were lower. In the echocardiographic study, wall thinning in Group A was found to occur earlier (2.7±1.7 days vs 7.1±5.3 days, p<0.01) and left ventricular dilatation in Group A was observed significantly earlier than in Group B. The incidence of the improvement of infarct-site asynergy by echocardiography was frequent in Group A. The exercise duration time in the exercise tolerance test by bicycle ergometer was short in Group A. In conclusion, we suggest that repetitive T wave inversion is due to the different processes of the formation of myocardial infarction, such as the degree of blood flow to the infarcted area in the acute stage, wall thinning, and left ventricular dilatation, which is known as expansion.View full abstractDownload PDF (905K) -
—Different Sequences and Enhanced MRI—Masanori HIROSE1995 Volume 55 Issue 1 Pages 19-32
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNinety-three pathologically proved breast diseases were examined by plain MRI in different sequences and enhanced MRI. The disease was breast cancer in 85 lesions and other diseases in 8. Detectability of breast cancer by plain MRI was 70-80%, and there was no significant difference in sequences. Of breast cancer, 96.3% were detected by enhanced MRI ; only 3 cases failed to be demonstrated. Detectability of breast cancer by enhanced MRI was as high as that of ultrasonography (95.1%) . Enhanced MRI revealed 87.6% of multicentric or daughter nodules (13/15) and three cases of muscle invasion, and the dete-ctability appeared superior to that by ultrasonography or mammography. We obtained three-dimensional images of breast cancer by MRI which an easy and clear understanding of the position of cancer especially those adjacent to the nipple or the chest wall and presence of multicentric nodules and muscle invasion. Sensitivity of detection of metastatic axillary lymph nodes was high (91.9%) while specificity was low (56.5%) . Enhanced MRI, especially 3 D MRI will be very valuable in the determination of staging of cancer and the operative procedure.View full abstractDownload PDF (14360K) -
—With Reference to Aging and The Presence of a Gall Stone—Masakuni SATO, Kazuhiko SOEJIMA, Mikio KANDA, Takahisa NAGAYAMA1995 Volume 55 Issue 1 Pages 33-44
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn this report, we discuss to the change in Oddi's sphincter (OS) according to aging, and to the change with or without a gall stone. We examined the Vater's ampulla from 150 autopsied cases, including 18 cases involving a gall stone. Sections were made in order to simultaneously observe the common bile duct, main pancreatic duct and common channel. With aging, the layer of OS, which includes the collagenous fibers and mucinous glands, between the bundles of smooth muscles, becomes thickened. Each of collagenous fibers, elastic fibers and mucinous glands were found to have increased significantly in the χ2-test. The increase of collagenous and elastic fibers seemed to reduce the compliance of the layer of OS and weaken the wringing force of OS. To compensate for the reduction in the wringing force, some muscles of the OS becomes thicken and proliferate, and the angle of the muscle bundle becomes changed near the vertical position against the longitudinal axis of the common channel. In comparision of the cases with and without a gall stone, there was a significant increase in the collagenous fibers and elastic fibers in the χ2-test in those with a gall stone. The increase of collagenous fibers seemed to be important in 40's or 50's ages, because the morbidity of the gall stone increases in the same period. On the other hand, the increase in the elastic fibers may simply be related to the general increase of morbidity in old age.View full abstractDownload PDF (9661K) -
—Effects on Lipid Peroxidation in Mouse Liver, Spleen and Brain After Whole-Body X-ray Irradiation—Noritaka SEINO1995 Volume 55 Issue 1 Pages 45-50
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTo investigate the radioprotective effect of dipyridamole in the aging mouse, the lipid peroxide content in aging mouse liver, spleen and brain irradiated by X-ray were measured both before and after injection of dipyridamole. The lipid peroxide content increased with aging from 2 months old to 16 months old in the mouse liver, spleen and brain. The content of lipid peroxide in the liver and spleen of the aging mouse was significantly increased in 7 days after whole-body irradiation with 8 Gy, but was unchanged in the brain. Dipyridamole, given before irradiation, significantly inhibited the increase of lipid peroxide after irradiation. These results suggest that dipyridamole may have radioprotective effects on aging mouse liver and spleen as well as on young mouse, and that inhibition of lipid peroxidation is a possible factor in the radioprotective effect of dipyridamole.View full abstractDownload PDF (748K) -
Tetsuya INOUE, Shigeki TANAKA, Hitoshi FUNATOMI, Keiji MITAMURA, Kenic ...1995 Volume 55 Issue 1 Pages 51-60
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is generally accepted that bradykinin plays an important role in the onset and progression of acute pancreatitis and in the development of multiple organ failure. In the present study, we examined the protective effects of Hoe 140, a new bradykinin B2receptor antagonist, on caerulein-induced pancreatitis in rats. Hoe 140 showed significant protective effects such as suppression of the increase of pancreatic wet weight and elevation of the plasma amylase level, and improvement in the histological changes in the pancreas was also observed. The elevation of plasma prolyl hydroxylase, which is an indicator of inflammation and tissue damage throughout the body, was suppressed by Hoe 140 administration. This study suggests that Hoe 140 has inhibitory effects not only on the progression of caerulein-induced acute pancreatitis but also on the tissue damage throughout the body which accompanies acute pancreatitis.View full abstractDownload PDF (2719K) -
Miwa MIKITANI, Jun OHNO, Syuichi FUKADO, Toshihiko UEDA, Ryohei KOIDE, ...1995 Volume 55 Issue 1 Pages 61-65
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCharacteristics of alpha 2-adrenoceptor on the intraocular pressure (IOP) lowering effect in the central nervous system was investigated in the pigmented rabbit. The TOP was decreased in a dose-ralated fashion by intracerebroventricular (ICV) injection of 0.1-10μg clonidine or 0.01-10μg apraclonidine (para-aminoclonidine) . The ocular hypotensive effect of 1μg clonidine was inhibited 62% by 10μg yohimbine and 17% by 10μg rauwolscine. The effect of 1μg apraclonidine was inhibited 54% by 10μg yohimbine and 79% by 10μg rauwolscine. α2-adrenoceptor displacement studies of yohimbine or rauwolscine were carried out with clonidine or apraclonidine. The IC50 value of apraclonidine was 447.7nM and clonidine was 200.0nM for displacement of rauwolscine. The IC50 value of apraclonidine was 83.1nM and that of clonidine was 85.4nM for displacement of yohimbine. These results suggest that α2-adrenoceptor for ocular hypotensive effect in the central nervous system of pigmented rabbit represents two pharmacological subtypes.View full abstractDownload PDF (534K) -
Kosei MIKITANI, Shigeki TANAKA, Yoshiaki TAKEUCHI, Hitoshi YOSHIDA, Hu ...1995 Volume 55 Issue 1 Pages 66-75
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCholecystokinin (CCK) is secreted from CCK secretory cells in mucosa of the upper small intestine. The secretory mechanism was studied using intestinal epithelial cells isolated from the mucosa of rat upper small intestine and CCK stimulating substances. The secretion of CCK from the isolated cells was confirmed by immunohistochemical and immunofluorescence staining and by measurement of CCK in the cells and culture medium using specific antibodies against CCK. Release of CCK was stimulated by the CCK stimulating substances, L-phenylalanine, phorbol ester, dibutyryl cyclic AMP, bombesin (BBS) and CCK releasing peptide. The stimulation by L-phenylalanine and BBS was dependent upon extracellular calcium ion. Staurosporine and N- (6-aminohexyl) -5-chloro-1-naphthalenesulfonamide (W-7) reduced the release of CCK from the BBS-stimulated cells. Isolated rat intestinal epithelial cells are thus useful in the study of the mechanism of CCK secretion.View full abstractDownload PDF (2736K) -
Kaori NAMBU, Susumu SENJYU, Ichiro USUI, Susumu NAKAMATA, [in Japanese ...1995 Volume 55 Issue 1 Pages 76-81
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 35-year-old woman in the 37th week of pregnancy was admitted to our hospital because of high fever and abdominal pain. On admission, serum and urinary pancreatic enzymes, serum total cholesterol (T-chol) and triglyceride (TG) were markedly elevated. A diagnosis of acute pancreatitis with hyperlipidemia was made. A Cesarean section delivery resulted in the birth of a healthy infant. This patient had an initially low level of lipoprotein lipase (LPL) activity. With the decreases of serum pancreatic enzymes and TG, LPL activity increased gradually, however, it was still below the normal level. Transient hyperlipidemia caused by the marked decrease of LPL activity due to pregnancy was thought to be the causative factor for acute pancreatitis in this case.View full abstractDownload PDF (4414K) -
Tsunehiro ENDO, Hiroaki KAWAI, Osamu SHOUKEI, Takeshi YAMAZAKI, Toshiy ...1995 Volume 55 Issue 1 Pages 82-86
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 62-year-old female visited our hospital with complaints of jaundice and fever. Laboratory data and ultrasonography suggested obstructive jaundice. Endoscopic retrograde cholangiography and percutaneous transhepatic cholangiography was performed under the diagnosis of choledocholithiasis. These showed multiple stones in the enlarged common and intrahepatic bile duct. In compliance with the patient's wishes, we used endoscopic therapy (PTCS, EHL and EST) and all stones disappeared. therefore, based on these result, we emphasize the possibility of endoscopic therapy in variable cases of choledocholithiasis.View full abstractDownload PDF (3956K) -
Ichiro USUI, Yasushi AKITA, Masazumi OGAWA, Masahiko IWANAGA, Takashi ...1995 Volume 55 Issue 1 Pages 87-91
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of lymphangioma of the large intestine is reported. In July 1993, a 39-year-old male visited our hospital with the complaint of upper abdominal pain. He underwent a barium enema study and colonoscopy for close examination. The barium enema study demonstrated a well demarcated, smooth-surfaced, radiolucent polypoid lesion at the S-D junction of the large intestine. Endoscopic examination revealed a soft submucosal tumor in the same area. These findings were strongly suggestive of lymphangioma. Endoscopic ultrasonography (EUS) showed echo-free spaces which were compartmentalized with a high echoic layer in the submucosa of the tumor. Lymphangioma of the large intestine was clearly diagnosed by EUS. Endoscopic polypectomy was performed and histopathological examination finally confirmed it to be lymphangioma. Recently, EUS has been suggested to be very useful for the differential diagnosis of colonic submucosal tumors. Lymphangioma of the large intestine is comparatively rare. This case was clearly diagnosed by EUS and the lymphangioma was effectively resected by endoscopic polypectomy.View full abstractDownload PDF (4144K) -
Tomio KAYAMA, Hiroki SUGAHARA, Hidefumi HIROSE, Tetuo TUKAHARA, Etuo F ...1995 Volume 55 Issue 1 Pages 92-96
Published: February 28, 1995
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 28-year-old male visited our hospital because a 4 year pain in left heel. Swelling and tarsal tunnel syndrome were found. Due to suspicion of a malignant tumor based on the clinical examination findings, operation was carried out. The tumor appeared from the aponeurosis plantaris and consisted compressed the nerve plantaris lateralis. Amputation below the knee was performed due to the malignant results of the immediate pathological diagnosis. The pathological diagnosis of the tumor was clear cell sarcoma (CCS) . CCS is characterized by a long clinical course and high mortarity. The therapeutic treatment has not been established but it is possible to decrease the size of the tumor by “CYVADACT”therapy pre-operatively. We report a case in whom the pre-operative chemothrapy was effective, and literature review of pertinent chemothrapy.View full abstractDownload PDF (4417K)
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