Abstract
An autopsy case of pleomorphic carcinoma of the gall bladder is reported. An 81-year-old woman was admitted complaining of upper abdominal pain and hepatomegaly. Laboratory data showed elevated serum levels of CEA and CA19-9, and abdominal CT and US revealed SOL in the liver. Cytological findings of the ascites disclosed hepatoma-like tumor cells, showing large atypical mono/multi nuclear cells with some prominent and large eosinophilic nucleoli. PAS-positive granules were present in the cytoplasma. At autopsy, white tumorous tissue seen in the gall bladder, showed a direct invasive growth pattern to liver. Histologically, severe atypical large tumor cells and bizarre cells were seen, showing typical histological characteristics of pleomorphic carcinoma. Focally, tubular adenocarcinoma was associated. Immunohistologically, some tumor cells were positive for EMA, and others were positive for vimentin. From these findings, pleomorphic carcinoma was considered to be deepithelialized carcinoma which originated from the cholecystic mucosa.
