Abstract
Normovolemic hemodilution was studied with SALIN-HES in adult mongrel dogs anesthetized with halothane, nitrous oxide, and oxygen. Dogs were divided into two groups : a dopamine (DOA) group and a dobutamine (DOB) group. Hemodynamics and organ blood flow were studied with DOA and DOB at dosages of 5 and 10 μg/kg/min. Organ blood flow in renal cortex, renal medulla, and liver was measured with the hydrogen clearance method, and the percentage of cardiac output to each organ was calculated.
As a result of normovolemic hemodilution, increases in the maximum rates of change of left ventricular pressure (LVdp/dt max) and cardiac index and a decrease in systemic vascular resistance were found in both groups. In the DOA group, LVdp/dt max was increased with both dosages. In the DOB group, heart rate and LVdp/dt max were increased. Blood flow in the renal medulla was significantly increased in the DOA group. In the DOB group, blood flow in the renal cortex and medulla were not changed ; however the percentage of cardiac output to the renal cortex was significantly decreased. Blood flow in the liver was not significantly increased in either the DOA or DOB group. These findings suggest that it is difficult to maintain renal and liver blood flow when either DOA or DOB is used.
