Abstract
Intraoperative rapid diagnosis of ovarian tumors is important to determine the appropriate surgical procedure. A retrospective study was conducted to determine the accuracy of intraoperative frozen sections. Intraoperative frozen section diagnoses were compared with the final histologic diagnosis. The benign (10), borderline (10), and malignant (10) cases by rapid diagnosis were analyzed for the DNA ploidy pattern using LSC. 146 ovarian tumor patients underwent intraoperative rapid diagnosis between May 1997 and December 2001. Among 82 ovarian epithelial neoplasms (surface epithelial and stromal tumors), 35 were benign, 15 were borderline and 32 were malignant. An analysis of DNA ploidy using LSC showed that two tumors out of 5 under diagnosed borderline tumors had an aneuploid pattern. Three cases had a diploid pattern. All 10 benign cases had a diploid pattern. 6/10 borderline tumors had an aneuploid pattern. Eight tumors out of 10 malignant tumors had an aneuploid pattern. In this study, in intra-operative rapid diagnosis of ovarian tumors, sensitivity of borderline ovarian tumors was elevated with DNA analysis by LSC. LSC will be one of the supportable methods for intraoperative diagnosis.
