Abstract
The thyroid carconoma is different from other head and neck malignant tumors. The thyroid could have various tumors from the viewpoint of pathology as well. Most of these tumors is well differentiated carcinoma, which the growth is very slow and survival rate after surgery is usually good. However, there are some types which will metastasize to lymph node early in the stage such as occult cancer. In addition, there are some types that extend beyond the thyroid capsule, which causes the surgical removal of thesurrounding internal organs such as the trachea. This is a very interesting tumor. We measured p53, Ki-67, C-erb B2, E- cadherin, β-catenin, and examined the correlation with the clinical parameters. We researched the relationship between the biological movement and the thyroid gland cancer by unifying these data to see if these data could be a convalescence factor of thyroid gland cancer. It was proved that in the T classification, which is the size of tumor, and in the simulatneous expression and metastasized lymph node, p53 and/or Ki-67 were detected. Furthermore, in occult cancer, there is p53 as well as an abnormality in the E- cadherin. However, regarding the connection between the data and the state of the cancer, there was no physical evidence to relate the survival rate. The reason for this result is largely due to the fact that thyroid gland cancer is operative except for the distant metastasis. Even if the tumor is big and metastasized to the lymph node, it could still be removed by surgical means to save the patient, so the survival rate is not affected by this. However the result, it is still possible to say that both p53 and/or Ki-67 could be warnings for close observation.
