Abstract
The central effects of CS-088, angiotensin II type 1 receptor blocker on intraocular pressure (IOP) in male pigmented rabbits were investigated. Fifty μL CS-088 was administered to the lateral eye, orally, or intravenous by from the auricular vein (i.v.) . For intracerebroventricular (icv) treatment, a guide cannula was inserted two weeks before injection into the lateral ventriulus following Fifkova's brain map ; ten μL CS-088 was subsequently injected (5 μL/min) to the lateral ventriculus. After the treatments, IOP was measured with a pneumatonometer and blood pressure (BP) at the right lower limb was monitored without anesthesia. IOPs were significantly decreased bilaterally after 30 min topical administration of 6 % CS-088 to the lateral eye compared to a phosphate buffer treatment of the control group (p<0.05, n=6) ; BP showed no change. With 6 % CS-088 oral administration, TOP and BP were not changed. TOP and BP decreased significantly at 60 min after 6 % CS-088 i. v. treatment (p<0.05, n=5) . IOP did not change with 0.06% CS-088 icy treatment. These results suggest that topical use of CS-088 might decrease IOP in the pigmented rabbit by a sympathetic nerve effect and its local effect.
