The Development of the Magnetic Sensor for Detecting the Residual Brain Tumor: Optimal Dosage and Safety of Magnetic Cationic Liposome

Abstract

We developed a new magnetic sensor for residual brain tumor using magnetite enveloped by cationic liposome (MCL) . First, we evaluated the dynamic state of MCL on MRI following local injection into the rat brain and confirmed the safety of MCL by observing the rat's behavior and performing histological examination. In this study, 1.5 mg/ml concentration of MCL showed proper contrast-enhancing effect and did not transport to the liver or kidney. Local injection of MCL into the rat brain did not induce abnormal behavior and no abnormal inflammation was observed in histology. These study suggested the possibility of developing a new technique for detecting brain tumor.