Abstract
The synergetic effect of whole body vibration (WBV) and parathyroid hormone (PTH) on bone healing was evaluated using ovariectomized mice. Mice underwent the drill-hole surgery on the right tibial diaphysis at 11 weeks of age and divided into C (n=14), W (n=12), P (n=14), and WP (n=11) groups. From the day after the surgery, mice in W and WP were exposed to 0.3-g WBV at 45 Hz for 20 min/day, and mice in P and WP received subcutaneous PTH injection (30μg/kg/day). The tibiae were harvested 20 days after the surgery, and the microstructure and material properties of regenerated bone were analyzed by μCT and infrared microspectroscopy. Results showed the synergetic effect of WBV and PTH.
