2014 年 52 巻 Supplement 号 p. SY-35-SY-36
Several kinds of imaging tools are used both in basic sciences and clinical diagnoses, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound imaging (US). Among these, CT, MRI and US are categorized as morphological imaging technologies, although some molecular imaging trials are undertaken these days. PET, SPECT and optical imaging are mainly used for molecular imaging. Molecular imaging probes are composed of signal molecules and targeting molecules, and nano-particles can be used as a targeting molecule. Especially, nano-particles have great advantages in making multimodal imaging probes, since multiple kinds and/or amount of signal molecules can be combined to them.Herein, we discuss the advances and disadvantages of each imaging technique, and in vivo molecular imaging with nano-particles would be discussed by showing our practical examples.