解説特集 多階層生体機能学の創成に向けたシミュレーション研究の成果と進展
心臓興奮伝播とその破綻による不整脈発生機構
2015 年 53 巻 3 号 p. 123-129
詳細
2015 年 53 巻 3 号 p. 123-129
Cardiac impulse propagation is determined by complex interactions between electrical activity of myocardiocytes, intercellular electrical communication and the myocardial tissue structure. A special form of conduction that underlies cardiac arrhythmias, including tachycardia and fibrillation, involves circulating excitation, spiral wave reentry. In this type of impulse propagation, curvature of the propagating excitation wavefront plays additional important roles. This brief review describes results from mathematical simulations and animal experiments to define mechanisms of normal and abnormal impulse conduction in the heart.
