生体医工学
Online ISSN : 1881-4379
Print ISSN : 1347-443X
ISSN-L : 1347-443X
解説特集 多階層生体機能学の創成に向けたシミュレーション研究の成果と進展
細胞と組織階層を繋ぐ新たな心臓興奮伝導機構:Electric Field機構
津元 国親倉智 嘉久
著者情報
ジャーナル フリー

2015 年 53 巻 3 号 p. 138-143

詳細
抄録

The accurate propagation of action potentials is indispensable for normal contractile function of the heart. The underlying mechanism of action potential propagation under physiological conditions has been explained by the gap junction responsible for electrical interaction between cardiomyocytes. However, many phenomena under pathological conditions cannot be explained by the gap junctional mechanism. Therefore, the presence of an alternative mechanism besides the gap junctional mechanism has been suggested. In this review, we introduce simulations of action potential propagation in a myofiber model incorporating a novel mechanism resulting from the morphology of cardiomyocytes and the subcellular distributions of functional proteins such as ion channels and transporters, in addition to the conventional gap junctional mechanism. It is possible that the novel conduction mechanism incorporating subcellular distributions of functional proteins plays an important role in homeostasis of excitation propagation in the diseased heart.

著者関連情報
© 2015 社団法人日本生体医工学会
前の記事 次の記事
feedback
Top