Abstract
Cancer death is mainly caused by metastasis via lymphatic or cardiovasucular system. Normally, solid tumor has a high interstitial fluid pressures (IFP) and it makes difficult to deliver drugs into the tumor region. It has been reported that IFP increases in tumor or pre-tumor regions because of tumor vessels and impaired lymphatic vessels, and high IFP may have correlation with lymph node metastasis. Although it is reported that drugs are delivered to metastatic lymph node via lymphogenous, there is no reliable methods to evaluate chemotherapy-induced treatment effect. Here we show the correlation between intermodal pressure (INP) and tumor-bearing lymph node progression / degression caused by chemotherapy by CDDP. We found that tumor-bearing lymph node was progressed with increasing INP, and chemotherapy decreased. There was no significant change in of blood vessel density in lymph node. Our results demonstrate an importance of INP for assessing tumor-bearing lymph node. We anticipate that this study contributes to develop an evaluation method of diagnosis and treatment for lymph node metastasis.
