抄録
We have proposed drug delivery systems (DDS) using shock waves to apply in the fields of biomedical engineering. For developing the microcapsules including a gas bubble, the penetration force of micro jet should be controlled by shock wave strength (power), wave form of pressure, and capsule geometry and material properties. Especially and mechanical properties of membrane, the gas ratio in liquid, and thickness of the membrane are important parameters for changing the penetration strength of micro jet in the microcapsule. In this presentation, Deformation process of a capsule and a bubble were observed by microscopy. It was found that there are three modes such as no oscillation, oscillation, disintegration after working pressure wave on the microcapsules. It was also found that these modes depend on gas ratio in the liquid capsule, membrane thickness, pressure amplitude and frequency. And these results correspond to the result of mathematical analysis of deformation process of a bubble in the capsule, such as effects of initial internal pressure of a bubble and gas ratio on the deformation process.
