抄録
Brain machine interfaces (BMIs) using intracranial electroencephalograms (electrocorticograms) are a promising candidate of the clinical application of high performance BMIs. We demonstrated that high frequency band activity is an excellent feature to decode movement onset and type, independent of the severity of motor dysfunction. Using the decoding features, real time control of a robotic arm was successfully performed by the patients that brain surface electrodes were placed to treat intractable epilepsy or intractable pain. We started a clinical trial in severe ALS patients using a wired BMI system involving the temporary placement of newly-developed personalized electrodes. A fully implantable wireless system is indispensable for clinical application of invasive BMIs to reduce infection risk. We are now developing the implantable system, which includes a 128-ch integrated amplifier circuit, 3D personalized high density electrodes, a wireless data transfer system and a wireless battery charger. We aim to put the implantable system to clinical use as soon as possible.
