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Objective: We investigated right (RV) and left ventricular (RV and LV) function, dyssynchrony and ventricular interdependence in acute and chronic RV pressure overload (RVPO). Methods: RV and LV functions were analyzed by speckle-tracking echocardiography in APTE (n =37), CPAH (n =36), and Controls (n =33). The standard deviation of the heart rate-corrected time-to-peak regional systolic strain (PSS-dyssynchrony) and displacement (PSD-dyssynchrony) was used to quantify RV and LV dyssynchrony. Results: Both the APTE and CPAH groups had impaired RV and LV myocardial strain and large dyssynchrony compared with the Control group. RV and LV myocardial performance indices (MPI) were also abnormally high both in the APTE and CPAH groups. Pulmonary vascular resistance in the APTE group and RV global PSS in the CPAH group were independently associated with RV MPI, and LV longitudinal PSD-dyssynchrony in the APTE group and eccentricity index and heart rate in the CPAH group were independently associated with LV MPI. Conclusion: RVPO reduces ventricular function and generates dyssynchrony in the both ventricles. Pathophysiological mechanisms that regulate ventricular interdependence are different in acute and chronic RVPO.
