Abstract
We have previously proved prefrontal hemodynamic change in autism spectrum disorder (ASD) subjects according to switching task using near infrared spectroscopy (NIRS) lacks synchronizing evoke of oxygenated hemoglobin, although the task performance rates were almost equivalent to the controls. Therefore, next we have applied the neurofeedback (NFB) system using NIRS for ASD subjects to establish their task-related PFC activity control. The NFB system using wireless NIRS was preliminarily applied to 4 ASD individuals with a session consists of 7 consecutive trials. They partially showed improvement in PFC blood oxygenation response to the self-stimulation of neurofeedback by plotting oxy-Hb and d(oxy-Hb)dt and detect barycentric points appearance. Additionally, the average data of working memory and non-working memory switching task, stroop test, anxiety test, self-evaluation test, and mood test, were all improved during the NFB training , as well as follow-up check. These results suggests us that it might be possible to apply NIRS as a non-invasive sub diagnostic tool as well as active supporting tool for ASD subjects.
