Abstract
The auditory mismatch negativity (MMN) is a component of event-related potential (ERP) that corresponds to a response to an odd sound stimulus among a sequence of uniform stimuli. Auditory MMN is considered as an index of automatic context-dependent information processing and auditory sensory memory, and previous clinical studies reported deficit of MMN in schizophrenia patients. To further understand the difference in auditory signal processing between healthy controls and schizophrenia patients, we utilized the EEG/MEG data analysis tool of SPM8, the generalized functional neuroimaging software, to localize cortical sources for the auditory MMN response. The advantage of using SPM8 in the analysis of MMN-ERP is that the reconstructed sources are represented in the normalized brain coordinates and thus it is available to statistically compare the volumetric cortical activities between participants. This paper describes how to process EEG data that were measured from conventional commercial system (Biosemi .bdf file) in the SPM8 to extract MMN responses, localize regional brain activities, and perform voxel-based statistical analysis between participant groups.
