Current and Future Perfusion Technology for Organ Engineering

Abstract

Ex vivo organ machine perfusion is a promising technology for organ preservation and resuscitation for solid organ transplantation. There are various researches to preserve the organ functions and to access the organ viabilities with the perfusion technology. In the case of the kidney preservation, some clinical machine perfusion systems have been developed as commercial products in EU and USA. Recently, donation after cardiac death hearts were resuscitated with the treatment by the perfusion technology and transplanted it as clinical trial studies. The perfusion technology has many possibilities. However, many consideration points are remained to enhance the perfusion technology and to develop future technologies. Combination of the perfusate and the profusion technology is essential point and temperature, oxygenation, pressure and flow rate are particularly important conditions to consider the perfusion technology. In this presentation, the current perfusion technologies are introduced and discussed important conditions to preserve and resuscitate organs. Furthermore, the future perfusion technology as the organ engineering is suggested for not only the solid organ transplantation but also the regenerative medicine and the cell medicine.