灰化ウシ骨の再生骨用担体としての利用とその特性評価

抄録

Calcined bovine trabecular bone is an attractive material for bone tissue engineering, due to low-cost, natural porous structure, and absent of any immunogens, i.e., type I collagen and the other osteoproteins, which are removed out by calcination process. To determine an optimal calcination temperature, in our previous studies, the chemical and mechanical characteristics of calcined bovine trabecular bone were investigated. However, the bio-absorbability of calcined bovine trabecular bone is not understood enough. Bioabsorption is crucial for complete tissue replacement, and realized by osteoclastic matrix resorption and chemical dissolution to body fluid. In this study, to evaluate the biosolubility of calcined bovine bone, change in calcium amount released from calcined bovine bone in simulated body fluid was investigated, additionally the microscopic structure of the bone surface was observed after immersing in the fluid. The results were compared with those of HA and b-TCP.