Detection of Predisease States by Dynamical Network Biomarkers

Abstract

In this talk, I will review bases of theory of DNB (Dynamical Network Biomarkers) analysis and its application to detection of predisease states. The DNB analysis is based on bifurcation theory for a complex biological network that triggers a disease, and can detect a predisease state bifurcating from a healthy-state attractor to a disease-state attractor. The DNB analysis can realize very early personalized diagnosis and preemptive medicine for various complex diseases.