細胞機能制御タンパク質を提示した新規細胞外マトリックスの構築

抄録

We have developed artificial extracellular matrix (ECM) proteins by genetic engineering. Our constructed ECM proteins were consisted of structural units derived from elastin-like peptides and functional peptides derived from natural ECMs or synthetic peptides. These ECM proteins can be added abilities not only for cell adhesion but also for enhancement of cellular differentiation by combination of several functional peptides. Moreover, to regulate cellular functions, proteins such as growth factors were tethered to our constructed ECM proteins. Recently, we have developed a strategy for induction of cellular differentiation by introduction of transcription factor proteins into cells. Based on this strategy, transcription factor protein tethered ECM was developed. In here, those ECMs tethering proteins for regulation of cellular functions are introduced.