Transactions of Japanese Society for Medical and Biological Engineering
Online ISSN : 1881-4379
Print ISSN : 1347-443X
ISSN-L : 1347-443X
Proceedings
Central chemoreflex activation resets the baroreflex neural arc without compromising its dynamic and static function
Keita SakuTakafumi SakamotoTakeshi TohyamaTakuya NishikawaTakuya KishiKenji Sunagawa
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2016 Volume 54Annual Issue 27PM-Abstract Pages S175

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Abstract

BACKGROUNDS: While hypercapnia activates central chemoreflex and induces sympatho-excitation, its interaction with the baroreflex regulation of sympathetic nerve activity (SNA) has not been quantified. This study aimed to examine the impact of the central chemoreflex on the baroreflex function using an open-loop analysis. METHODS/RESULTS: In 7 anesthetized SD rats, we controlled intra-sinus pressure (CSP, baroreceptor sensed pressure) and recorded SNA and aortic pressure (AP). Hypercapnia was induced by inhalation of 3% CO2 gas. Hypercapnia markedly increased SNA (δSNA=53.4±7.1%, p<0.01) irrespective of CSP, indicating the resetting of the neural arc (CSP-SNA relation). In contrast, the peripheral arc (SNA-AP relation) did not change. The transfer function of the neural arc approximated a high-pass filter, while that of the peripheral arc approximated a low-pass filter. Hypercapnia did not affect either neural or peripheral arc transfer function. CONCLUSION: Chemoreflex activation reset the baroreflex neural arc upward without compromising its dynamic and static function.

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© 2016 Japanese Society for Medical and Biological Engineering
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