Hypertension treatment is important to prevent cardiovascular disease. The simulation model has potential to be applied to the treatment. In this study, we evaluated changes in upper limb's blood pressure by increasing lower limb's vascular resistance with simulation model and compared them with human data. We used entire cardiovascular system as a computational model. The arterial system was consisted of 88 vessels coupled with a lumped parameter model, which contains peripheral vessels and capillaries. The brachial blood pressure changes were caused by increasing vascular resistance of the tibial artery. Actual measurements were carried out by cold stimulation to the lower limbs.As results, the simulated data showed the blood pressure increase from 136 / 76 to 143 / 80 mmHg, which were similar to the human data (from 123/66 to 129/73 mmHg) [Conclusion] The entire simulation model recreated pressure change of upper limbs caused by vascular resistance increase of different artery.
