2017 Volume 55Annual Issue 4AM-Abstract Pages 266
We examined the anti-tumor effects by photothermal action derived from near-infrared (NIR) irradiation combined with DDS type photoabsorbing agent, ICG lactosome (ICGm). A subcutaneous tumor (Colon26) mice model was intravenously administered with ICGm, The tumor was then irradiated by a laser (808 nm) under several conditions while measuring tumor surface temperature (TST) by non-contact thermometer. A positive correlation was confirmed between the maximum TST (℃) and the power density (mW/cm2) of irradiation. In addition, under a constant power density (750 mW/cm2) anti-tumor effects depended on the maximum TST regardless of the duration of irradiation time (s). When TST reached at > 43℃ during irradiation, tumors were shrank with the possibility of 100%, while almost all of the tumors were not shrank when TST did not reach at 43℃. These results suggest that a temperature dosimetry during NIR irradiation combined with ICGm admistration provides definite anti-tumor effects.
