Network analysis mainly on Anterior cingulate cortex of an epilepsy patient and normal person

Abstract

Akinetic mutism has a lack of intention to act.Therefore, we set the region of interest as anterior cingulate cortex(ACC), which is related to the intention of behavior in DMN and has a connection to motor cortex(MC) and somatosensory cortex(SC). We performed ROI-based functional connectivity analysis on 5 epileptic patients who underwent callosotomy. As a result, 1 out of 2 who developed acute transection syndrome(ATS) had a correlation with MC and SC for ACC before surgery, but the correlation disappeared after surgery. To examine this result, we performed a similar analysis on the brain fMRI data of healthy subjects and compared it with this result. As a result, healthy subjects have correlation with MC and SC for ACC, and the above findings are considered to occur when ATS develops due to callosotomy. ATS is thought to be due to the disappearance of connection to MC and SC for ACC.